NDLI: A simplified blood sampling scheme in FDG-PET studies

Content Provider	IEEE Xplore Digital Library
Author	Bentourkia, M. Bol, A. Michel, C. Coppens, A. Sibomana, M. De Volder, A.G.
Copyright Year	1998
Description	Author affiliation: Positron Tomograhy Lab., Louvain Univ., Louvain-la-Neuve, Belgium (Bentourkia, M.)
Abstract	Quantitative measurement of brain glucose metabolism with positron emission tomography (PET) and fluorodeoxyglucose (FDG) involves arterial blood sampling to estimate the delivery of radioactivity to the brain. Usually, for an intra-venous bolus injection of 30 sec duration, an optimal manual sampling requires more than 25 blood samples since a frequency of 1 sample every 5 sec or less is necessary to determine the peak activity in arterial plasma during the first 2 minutes after injection. In the present work, 13 standardized sampling times were shown to be sufficient to accurately define the input curve. This standardized input curve was subsequently fitted by a polynomial function for its rising part and by spectral analysis for its decreasing part. Using the measured, the standardized as well as the fitted input curves, the regional cerebral metabolic rate for glucose (rCMRGlc) was estimated in 32 cerebral regions of interest (ROIs) in 20 normal volunteers. Metabolic values were obtained by both the autoradiographic method (ARG) and the kinetic analysis of dynamic data (DYN). Comparison of rCMRGlc values obtained with the measured and the fitted input curves showed that both procedures gave consistent results, with a maximal relative error in mean rCMRGlc of about 1% in ARG and 2% in DYN studies. This input curve fitting technique which was not dependent on the peak time occurrence, allowed an accurate determination of the input curve shape from reduced sampling schemes.
Starting Page	1711
Ending Page	1715
File Size	514309
Page Count	5
File Format	PDF
ISBN	0780342585
ISSN	10823654
DOI	10.1109/NSSMIC.1997.670647
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	1997-11-09
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Blood Sampling methods Sugar Positron emission tomography Biochemistry Frequency Plasmas Polynomials Spectral analysis Kinetic theory
Content Type	Text
Resource Type	Article

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