NDLI: Design of a microvolumetric blood counter/sampler for metabolic PET imaging in rats and mice

Content Provider	IEEE Xplore Digital Library
Author	Lapointe, D. Cadorette, J. Rodrigue, S. Rouleau, D. Lecomte, R.
Copyright Year	1998
Description	Author affiliation: Dept. of Nucl. Med. & Radiobiol., Sherbrooke Univ., Que., Canada (Lapointe, D.)
Abstract	Quantitative metabolic imaging in small animals with positron emission tomography (PET) requires the determination of the tracer concentration in whole blood, arterial plasma and metabolites as a function of time. A blood counting and sampling system was designed to simultaneously measure the time-activity curve as microvolumes of blood are collected. The system consists of a flow-through counter made of a plastic scintillator to detect positrons and of a computer-controlled blood sampler based on the concept of bubble segmentation. The number and size of samples, the withdrawal speed and the sampling time are all programmable and can be modified on-line. Samples as small as 10 /spl mu/l can be repetitively obtained from an implanted arterial catheter in the femoral vein or artery of small rats (150 g) or the jugular vein of mice (20 g). For medium sampling speed (100 /spl mu/l/min) at a constant rate, the standard deviation of the sample activity is typically less than 4%. By cutting the tubing at the bubbles at the end of the experiment, samples are made available for further processing and biochemical analysis. This apparatus has become an essential tool for quantitative animal PET studies, allowing easy, reliable sampling at a low cost.
Starting Page	1399
Ending Page	1403
File Size	556570
Page Count	5
File Format	PDF
ISBN	0780342585
ISSN	10823654
DOI	10.1109/NSSMIC.1997.670582
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	1997-11-09
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Blood Counting circuits Positron emission tomography Sampling methods Radiation detectors Animals Veins Plasma measurements Plastics Catheters
Content Type	Text
Resource Type	Article

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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