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| Content Provider | IEEE Xplore Digital Library |
|---|---|
| Author | Yu-Hwa Fang Liang-Chih Wu Kao, T. |
| Copyright Year | 2001 |
| Description | Author affiliation: Inst. of Biomed. Eng., Nat. Yang-Ming Univ., Taipei, Taiwan (Yu-Hwa Fang) |
| Abstract | The quantitative determination of LCMRGlc (local cerebral metabolic rate of glucose) is one of the advantages for FDG-PET ([/sup 18/F]2-fluoro-2-deoxy-D-glucose positron emission tomography) in diagnosis of brain functions. However, in the FDG 3-compartment model, an input function made of arterial blood samples is necessary for the computation. Due to the invasion of arterial lines and inconvenience of the sampling schedule, FDG quantitative analysis is seldom performed in practice. To solve this dilemma, some methods have been used to simplify the sampling schedule. But one or two blood samples are still needed, or the estimated LCMRGlc may be seriously biased. This paper proposes a new composite technique based on two current methods to estimate the input function without any blood sample. Eighteen patients are tested with this new approach, together with current methods for evaluation. The results show that this new technique can provide reliable estimation of the input function, and the bias of K constants is also reduced when the estimated input function is used. |
| Starting Page | 2759 |
| Ending Page | 2762 |
| File Size | 470626 |
| Page Count | 4 |
| File Format | |
| ISBN | 0780372115 |
| ISSN | 1094687X |
| DOI | 10.1109/IEMBS.2001.1017356 |
| Language | English |
| Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Publisher Date | 2001-10-25 |
| Publisher Place | Turkey |
| Access Restriction | Subscribed |
| Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Subject Keyword | Blood Positron emission tomography Sugar Sampling methods Cyclotrons Hospitals Processor scheduling Statistical analysis Biomedical engineering Performance analysis |
| Content Type | Text |
| Resource Type | Article |
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