NDLI: An integrated microfluidic blood sampler for determination of blood input function in quantitative mouse microPET studies

Content Provider	IEEE Xplore Digital Library
Author	Hsiao-Ming Wu Guodong Sui Cheng-Chung Lee Ladno, W. Quake, S.R. Hsian-Rong Tseng Sung-Cheng Huang
Copyright Year	2005
Description	Author affiliation: Dept. of Molecular & Med. Pharmacology, UCLA, Los Angeles, CA, USA (Hsiao-Ming Wu)
Abstract	In this study, we developed and constructed a blood sampling system on an integrated microfluidic platform to withdraw sub-microliter blood samples from mice up to a rate of one to two samples per second. On one microfluidic chip, eighteen blood samples can be collected on designated wells and can be retrieved later for further analysis. The chip is flushed with Heparin lock flush between sample collections. The device is remotely controlled by a user-friendly interface and can be programmed to take samples at specific time interval. Preliminary results show that both saline solution and FDG blood samples (/spl sim/220 nano-liter/sample) can be taken with a consistent volume (variation < 2.2% s.d.) at a rate of one sample per second. Although the volumes are small, the FDG activities in blood samples are detectable with low variability (<1.2%). Our study demonstrates the feasibility of deriving input function from mice using a microfluidic blood sampling device. The blood loss (<100 /spl mu/l) and the impact on physiological change is expected to be minimized.
Starting Page	4
Ending Page	1661
File Size	675815
Page Count	1658
File Format	PDF
ISBN	0780392213
ISSN	10957863
DOI	10.1109/NSSMIC.2005.1596638
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2005-10-23
Publisher Place	Puerto Rico
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Blood Microfluidics Mice Sampling methods Positron emission tomography Biomedical imaging Animals Plasma measurements Biomedical monitoring In vivo
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

The feasibility of performing longitudinal measurements in mice using small animal PET imaging and a microfluidic blood sampling device

Automatic Control System of a Microfluidic Blood Sampler for Quantitative microPET Studies in Small Laboratory Animals

A Public Domain Dynamic Mouse FDG MicroPET Image Data Set for Evaluation and Validation of Input Function Derivation Methods

Design of a microvolumetric blood counter/sampler for metabolic PET imaging in rats and mice

Cardiovascular transit times in mice by high temporal resolution microPET

Performing longitudinal measurements in rodents using small animal PET imaging

Characterization of Spillover and Recovery Coefficients in the Gated Mouse Heart for Non-Invasive Extraction of Input Function in microPET Studies: Feasibility and Sensitivity Analysis

An Activity-Subspace Approach for Estimating the Integrated Input Function and Relative Distribution Volume in PET Parametric Imaging

Dosimetry of PET tracers in mice using microPET scans as an input function

An integrated microfluidic blood sampler for determination of blood input function in quantitative mouse microPET studies

Similar Documents

The feasibility of performing longitudinal measurements in mice using small animal PET imaging and a microfluidic blood sampling device

Automatic Control System of a Microfluidic Blood Sampler for Quantitative microPET Studies in Small Laboratory Animals

A Public Domain Dynamic Mouse FDG MicroPET Image Data Set for Evaluation and Validation of Input Function Derivation Methods

Design of a microvolumetric blood counter/sampler for metabolic PET imaging in rats and mice

Cardiovascular transit times in mice by high temporal resolution microPET

Performing longitudinal measurements in rodents using small animal PET imaging

Characterization of Spillover and Recovery Coefficients in the Gated Mouse Heart for Non-Invasive Extraction of Input Function in microPET Studies: Feasibility and Sensitivity Analysis

An Activity-Subspace Approach for Estimating the Integrated Input Function and Relative Distribution Volume in PET Parametric Imaging

Dosimetry of PET tracers in mice using microPET scans as an input function

An integrated microfluidic blood sampler for determination of blood input function in quantitative mouse microPET studies