NDLI: Perinatal, maternal and antenatal associated factors for autism: A case control study

Content Provider	IEEE Xplore Digital Library
Author	Abdullah, M.N. Mohamad, W.M.Z.W. Abdullah, M.R. Yaacob, M.J. Baharuddin, M.S.
Copyright Year	2012
Description	Author affiliation: Department of Psychiatric, Medical School, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia (Yaacob, M.J.) \|\| Department of Statistics, Faculty of Computer and Mathematical Sciences, Universiti Teknologi MARA (Perak), Seri Iskandar, Malaysia (Abdullah, M.N.; Baharuddin, M.S.) \|\| Department of Community Medicine, Medical School, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia (Mohamad, W.M.Z.W.; Abdullah, M.R.)
Abstract	Autism disorders are a group of neurodevelopmental disorders which characterized into three main domains which are social interaction impairment, communication delay and repetitive or stereotypic behavior. Many studies had suggested that the risk factors for autism derive from three big factors namely environmental factors, genetic predisposition and vaccine induced. The aim of this study was to investigate the perinatal, maternal and antenatal associated factors on autistic disorder children at Hospital Pulau Pinang and Hospital Bukit Mertajam, Pulau Pinang. A case control study involving 312 cases and control was conducted using data retrieved from hospital records at Pulau Pinang hospital and Bukit Mertajam hospital from 2001 to 2008. The departments involved were Psychiatric, Obstetrics and Gynecology and Record and Management Department. All cases which met the inclusion and exclusion criteria were included in the study. Univariable and multivariable logistic regression were used to explore the perinatal, maternal and antenatal associated factors associated with autistic disorder children. There were seven associated factors contributed most to autistic disorder determination. The factors were maternal age [Adjusted Odds Ratio (OR): 1.41; 95% Confidence Interval (CI): (1.27, 1.57)], maternal smoking reported at first antenatal visit [Adjusted OR: 13.61; 95% CI: (1.87, 99.35)], birth asphyxia [Adjusted OR: 0.35; 95% CI: (0.11, 1.08)], psychiatric history [Adjusted OR: 54.94; 95% CI: (12.07, 250.04)], multiple gestation [Adjusted OR: 4.81; 95% CI: (1.86, 12.45)], parity for more than 4 [Adjusted OR: 0.11; 95% CI: (0.03, 0.47)], parity between 0 and 1 [Adjusted OR: 0.19; 95% CI: (0.07,0.55)], Chinese race compared to the Malay race [Adjusted OR: 10.11; 95% CI: (3.61, 28.30)] and Indian race compared to the Malay race [Adjusted OR: 5.14; 95% CI: (1.38, 19.16)]. The results suggested that autistic disorders were associated with perinatal, maternal and antenatal factors such as delivery, pregnancy and maternal characteristics.
Starting Page	144
Ending Page	148
File Size	231696
Page Count	5
File Format	PDF
ISBN	9781467316644
e-ISBN	9781467316668
DOI	10.1109/IECBES.2012.6498121
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2012-12-17
Publisher Place	Malaysia
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Maternal Antenatal Perinatal Retrospective Prenatal Parental Pregnancy Autism Autistic ASD Case Control Delivery Risk Factor
Content Type	Text
Resource Type	Article

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