NDLI: Monitoring system for degradation assessment of biodegradable metals using microdialysis and enzymatic-spectrophotometric analysis

Content Provider	IEEE Xplore Digital Library
Author	Dayou, S. Natasha, S. Corcoles, E.P. Hermawan, H.
Copyright Year	2012
Description	Author affiliation: Faculty of Biomedical Engineering & Health Science, Universiti Teknologi Malaysia, 81310 Skudai, Johor, Malaysia (Dayou, S.; Natasha, S.; Corcoles, E.P.; Hermawan, H.)
Abstract	One aspect less reported in biodegradable medical implants research is the interaction between the degradable materials with the surrounding implantation site monitored in real-time. This work introduces the use of microdialysis combined with enzymatic spectrophotometric detector as novel tool to monitor degradation of biodegradable metals. The system measures the degradation rate based on the concentration level of metal ion yielded from metal dissolution into the physiological solution. Microdialysis was used as sampling device and the analytes recovered were analyzed using a spectrophotometer via Mg colorimetric assay kit. Experimental results using Mg-0.7Ca alloy specimens showed a good correlation on the degradation kinetic approached by microdialysis sampling and by conventional weight change. With further enhancement by using biosensor, this technique offers practical means for characterizing degradation behavior of biodegradable metals in vivo.
Starting Page	243
Ending Page	246
File Size	1060925
Page Count	4
File Format	PDF
ISBN	9781467316644
e-ISBN	9781467316668
DOI	10.1109/IECBES.2012.6498098
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2012-12-17
Publisher Place	Malaysia
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Degradation Microdialysis Implant Spectrophotometer Magnesium alloy Biodegradable metal
Content Type	Text
Resource Type	Article

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