NDLI: Anti - oxidant coated liposome as the delivery system for papain based natural cosmetics

Content Provider	IEEE Xplore Digital Library
Author	Roslan, Nur Zatul Iradah Abdul Aziz, Azila Sarmidi, Mohammad Roji Aziz, Ramlan Abdul
Copyright Year	2010
Description	Author affiliation: Department, of Bioprocess Engineering, Faculty of Chemical Engineering, Universiti Teknologi Malaysia, 81310 Skudai, Malaysia (Roslan, Nur Zatul Iradah; Abdul Aziz, Azila; Sarmidi, Mohammad Roji) \|\| Chemical Engineering Pilot Plant, Universiti Teknologi Malaysia, 81310 Skudai, Malaysia (Aziz, Ramlan Abdul)
Abstract	Liposome is a topical delivery system that has evoked a considerable interest in the cosmetic industry. Liposome is biocompatible, biodegradable, exhibits low toxicity and has the ability to entrap both hydrophilic and lipophilic active materials [1]. Over the last decades, liposome has been intensively studied as nanocarriers for transdermal administration of drugs and skin care active ingredients [2]. Papain, a protease, is an exfoliating agent which has also been touted to be able to reduce the signs of aging. In this study, liposome was used to enhance the transdermal penetration of papain into the skin [2]. In addition, liposome also stabilizes papain and reduces skin damage due to direct exposure to papain. Liposome can be formed from pure L-a-phosphatidylcholine or from cheaper sources such as soybean lecithin. However, liposome from soybean lecithin can be oxidized easily due to its unsaturated fatty acid chains. To overcome this problem, in this work antioxidant was added to decrease liposome oxidation and thus increase stability. The liposome, which was at pH 6.5, was stored at 25°C and 4°C and the stability of the liposome was monitored up to sixty days. Coated liposome was found to be more stable than uncoated liposome regardless of storage temperature. After two months, the encapsulation efficiency of the coated liposome was approximately 80%, whilst the encapsulation efficiency of the uncoated liposome was approximately 74%. Percutaneous penetration study was conducted to assess the efficiency of the transdermal delivery of the liposome-papain through the skin. Results obtained from the analysis showed that liposome-papain effectively penetrated the skin. Various studies have suggested that liposome increases percutaneous penetration of compounds through interaction of vesicles with the stratum corneum [3] and that this penetration is responsible for the greater concentration of the active ingredient in the skin.
Starting Page	1
Ending Page	1
File Size	90131
Page Count	1
File Format	PDF
ISBN	9781424488537
e-ISBN	9781424488544
DOI	10.1109/ESCINANO.2010.5700962
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2010-12-01
Publisher Place	Malaysia
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Skin
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

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