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Cell-penetration efficiency of PEGylated multi-walled carbon nanotubes is dependent on cell types

Content Provider	IEEE Xplore Digital Library
Author	Jinping Cheng Yun Wah Lam Ya-Ping Sun Shuk Han Cheng
Copyright Year	2010
Description	Author affiliation: Department of Chemistry and Laboratory for Emerging Materials and Technology, Clemson University, Clemson, South Carolina 29634-0973, USA (Ya-Ping Sun) \|\| Department of Biology and Chemistry, City University of Hong Kong, Hong Kong (Jinping Cheng; Yun Wah Lam; Shuk Han Cheng)
Abstract	Carbon nanotubes (CNTs) have been widely investigated as one of the most promising nanomaterials in biomedical applications. Functionalization of CNTs with poly(ethylene glycol) diamine (PEG) is a recognized methodology with good solubility and biocompatibility. In this study, PEG conjugated (PEGylated) multi-walled CNTs (MWCNTs) were prepared and labeled with fluorophore FITC. Using fluorophore-conjugated PEGylated MWCNTs, we monitored their accumulation in transformed cancer cells and in normal cells. The intracellular accumulation of PEGylated MWCNTs was studied under confocal microscope and transmission electron microscope. At the same concentration and exposure time, PEGylated MWCNTs entered all three of the cancer cell lines tested much more efficiently than the three primary human fibroblast lines. This different cell-penetration efficiency was observed both in separate cell culture separate exposure conditions and in co-culture and co-exposure conditions. This study highlights that the cell-penetration efficiency of PEGylated MWCNTs is dependent on cell types, and possibly due to different metabolic rates in different cell types. Furthermore, the intracellular accumulation of PEGylated MWCNTs did not impair membrane integrity, and the treated cells remained normal morphology, indicating good biocompatibility of PEGylated MWCNTs. This study suggests that PEGylated MWCNTs can be developed as potential drug carrier with its intrinsic higher preference to tumor cells than normal cells.
Starting Page	203
Ending Page	208
File Size	4735811
Page Count	6
File Format	PDF
ISBN	9781612841526
ISSN	21596972
e-ISBN	9781612841540
DOI	10.1109/NANOMED.2010.5749835
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2010-12-05
Publisher Place	China
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Normal cell Microscopy Cell penetration Efficiency Humans Fibroblasts Fluorescence Carbon nanotubes Cancer cell Mice Biomembranes Cancer
Content Type	Text
Resource Type	Article

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