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| Content Provider | IEEE Xplore Digital Library |
|---|---|
| Author | Gi-Ja Lee Ji-Hye Kim Hun-Kuk Park Kyung-Hwan Jeong Hyun-Jung Kang Tae Won Lee |
| Copyright Year | 2010 |
| Description | Author affiliation: Dept. of Biomedical Engineering & Healthcare Industry, Research Institute, College of Medicine, Kyung Hee University, Seoul, Republic of Korea (Gi-Ja Lee; Ji-Hye Kim; Hun-Kuk Park) || Dept. of Nephrology, College of Medicine, Kyung Hee University, Seoul, Republic of Korea (Kyung-Hwan Jeong; Hyun-Jung Kang; Tae Won Lee) |
| Abstract | Atomic force microscopy (AFM) has become an important device to visualize various cells and biological materials for non-invasive imaging. The major advantage of AFM compared to the conventional optical and electron microscopes is its convenience. Sample preparation for AFM does not need special coating or vacuum as a procedure. AFM can detect samples even under the aqueous condition. Although the AFM is originally used to obtain surface topography of sample, it can measure precisely the interactions between its probe tip and the sample surface from force-distance measurements. Epithelial-to-mesenchymal transformation of tubular cells into myofibroblastic phenotype is an important mediator of renal injury in chronic nephropathy. It is generally known that angiotensin II (Ang II) plays a direct profibrotic role in the kidney, but the mechanism is unclear. In this study, we observed structural and mechanical changes in tubular epithelial cell after Ang II treatment using AFM. |
| Starting Page | 198 |
| Ending Page | 202 |
| File Size | 920119 |
| Page Count | 5 |
| File Format | |
| ISBN | 9781612841526 |
| ISSN | 21596972 |
| e-ISBN | 9781612841540 |
| DOI | 10.1109/NANOMED.2010.5749834 |
| Language | English |
| Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Publisher Date | 2010-12-05 |
| Publisher Place | China |
| Access Restriction | Subscribed |
| Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Subject Keyword | Atomic force microscopy Mechanical change Force Live tubular cells Surface morphology AFM Force-distance curve Angiotensin II Junctions Springs |
| Content Type | Text |
| Resource Type | Article |
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