NDLI: Measuring the molecular force of Burkitt's lymphoma patient cells using AFM

Content Provider	IEEE Xplore Digital Library
Author	Mi Li Lianqing Liu Ning Xi Yuechao Wang Zaili Dong Guangyong Li Xiubin Xiao Weijing Zhang
Copyright Year	2010
Description	Author affiliation: State Key Laboratory of Robotics, Shenyang Institute of Automation Chinese Academy of Sciences, Shenyang, 110016, China (Mi Li; Lianqing Liu; Ning Xi; Yuechao Wang; Zaili Dong; Guangyong Li) \|\| Department of Lymphoma, Affiliated Hospital of Military Medical Academy of Sciences, Beijing, 100071, China (Xiubin Xiao; Weijing Zhang)
Abstract	The treatment of Non-Hodgkin's lymphoma (NHL) was revolutionized by the approval of rituximab in 1997. Rituximab is a CD20-directed monoclonal antibody (mAb). Despite the great success of rituximab in the treatment of B-cell NHL, the urgent need is to enhance the efficacy due to the markedly variable patient responses. Hence elucidating the molecular mechanisms of rituximab's anti-cancer effect is of great significance. In the past decade the atomic force microscopy (AFM) has proven to be a powerful tool for characterizing the morphological properties and measuring the physiological interaction forces of single cells and single molecules under native conditions. In this work, the AFM single-molecule force spectroscopy(SMFS) was applied to quantitatively measure the CD20-rituximab binding force on Burkitt's lymphoma patient bone marrow cells. The experimental results will facilitate further investigation of the molecular mechanisms of rituximab's anticancer effect.
Starting Page	176
Ending Page	179
File Size	501007
Page Count	4
File Format	PDF
ISBN	9781612841526
ISSN	21596972
e-ISBN	9781612841540
DOI	10.1109/NANOMED.2010.5749829
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2010-12-05
Publisher Place	China
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Atomic force microscopy Scanning electron microscopy Force Cells (biology) Fluorescence Bones
Content Type	Text
Resource Type	Article

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