NDLI: On DNA Computers Controlling Gene Expression Levels

Content Provider	IEEE Xplore Digital Library
Author	Milenkovic, O. Kashyap, N. Vasic, B.
Copyright Year	2005
Description	Author affiliation: Dept. Electrical and Computer Eng., University of Colorado, Boulder, CO, 80309, USA. (Milenkovic, O.)
Abstract	The area of bio-molecular computing has recently witnessed a major paradigm shift. Rather then being used only as simple calculating units capable of solving hard combinatorial or numerical problems, DNA computers are increasingly becoming more tailored to operate like intelligent ent biological machines with unprecedented potentials. One example of applying DNA computers in such a new setting is in the area of logical control of gene expression levels. For this purpose, DNA computers are designed in such a way as to be able to diagnose some forms of cancer-related irregularities in a cell and release biological strands acting as inhibitors or activators of certain sets of genes. Such a controlaction can also be seen as a form of intra-cell cancer therapy, although it may also have other, more varied, purposes and goals. There are several important problems in the area of coding and network theory that arise in the context of developing DNA computers for controlling gene expressions. The two most important issues are that of minimizing diagnostics failure and of increasing the computational reliability of the system. The first question is intimately related to analyzing the operational principles. of networks of gene interactions, while the second is concerned with relating combinatorial characteristics of single- stranded DNA sequences to their hybridization affinities and secondary structures. In this paper, we will describe the state-of-the-art results and present some new relevant combinatorial and coding theoretic problems in this area.
Starting Page	1770
Ending Page	1775
File Size	146307
Page Count	6
File Format	PDF
ISBN	0780395670
DOI	10.1109/CDC.2005.1582416
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2005-12-15
Publisher Place	Spain
Access Restriction	Subscribed
Rights Holder	IEEE/EUCA
Subject Keyword	DNA computing Gene expression Biology computing Machine intelligence Cells (biology) Inhibitors Cancer Medical treatment Computer networks Computer network reliability
Content Type	Text
Resource Type	Article

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
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3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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