NDLI: Effects of Constitutive Gene Expression on the Dynamics of Random Boolean Networks

Content Provider	IEEE Xplore Digital Library
Author	Hallinan, J. Bradley, D. Wiles, J.
Copyright Year	2006
Description	Author affiliation: Newcastle upon Tyne Univ., Newcastle upon Tyne (Hallinan, J.)
Abstract	We investigate the effects of constitutive gene activation upon the dynamics of random Boolean networks using a suite of models. We find that constitutive activity leads to simpler state spaces, with fewer and larger basins of attraction. The major difference in patterns of basin number and distribution is seen between networks with no activation and those with a single constitutively active node. Increasing the proportion of constitutively active node intensifies, but does not qualitatively change, the observed patterns. The proportion of genes constitutively active interacts in a nonlinear way with other network parameters, such as average connectivity and proportion of inhibitory links. We conclude that constitutive gene activation has a fundamental effect on network behavior that has been overlooked in previous random Boolean network studies. It acts to constrain the start states of the networks, and the states which can be reached during development and differentiation, and we hypothesize that constitutive activation and repression of genes may help to guide the process whereby a single genetic regulatory network produces a range of different cell types.
Starting Page	2355
Ending Page	2361
File Size	372154
Page Count	7
File Format	PDF
ISBN	0780394879
DOI	10.1109/CEC.2006.1688599
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2006-07-16
Publisher Place	Canada
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Gene expression State-space methods Organisms Biological system modeling Genetics Biological cells Cancer Computer networks Predictive models Biology computing
Content Type	Text
Resource Type	Article

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
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3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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