NDLI: Human cardiac physiology in the phase plane: the ejection fraction to limit cycle area relation

Content Provider	IEEE Xplore Digital Library
Author	Eucker, S. Lisauskas, J.B. Singh, J. Kovacs, S.J.
Copyright Year	1999
Description	Author affiliation: Cardievascvlev Div., Washington Univ. Med. Center, St. Louis, MO, USA (Eucker, S.)
Abstract	Current physiologic parameters acquired during cardiac catheterization include the systolic, minimum, and end-diastolic left ventricular pressures, the ejection fraction, and the maximum and minimum rates of pressure rise and fall. To extract additional physiologic information from the left ventricular pressure (LVP) contour, we utilized phase plane analysis (dP/dt vs P) to study LVP. One cardiac cycle generates a closed loop, or limit-cycle, in the phase plane. We hypothesized that the area of the limit-cycle is related to the external work of the heart, which is a function of both pressure and volume. We investigated the relationship between limit-cycle area (A/sub LC/) and ejection fraction (LVEF). LVP and LVEF data acquired during cardiac catheterization in ten subjects were analyzed. We observed a linear relation between A/sub LC/ and LVEF with an R-value of 0.43. We conclude that new information characterizing LV function can be obtained from A/sub LC/.
File Size	106986
File Format	PDF
ISBN	0780356748
ISSN	1094687X
DOI	10.1109/IEMBS.1999.802281
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	1999-10-13
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Humans Physiology Limit-cycles Automatic logic units Catheterization Data mining Cardiology Biophysics Information analysis Laboratories
Content Type	Text
Resource Type	Article

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