NDLI: Analysis using a modified Luo-Rudy model of ventricular action potentials

Content Provider	IEEE Xplore Digital Library
Author	Ohuchi, K. Fukui, Y. Sakuma, I. Shibata, N. Kodama, I.
Copyright Year	1999
Description	Author affiliation: Tokyo Denki Univ., Saitama, Japan (Ohuchi, K.)
Abstract	To elucidate the subcellular mechanism underlying the after effects of high-intensity DC shocks, a small pore, which mimics reversible dielectric breakdown of the cell membrane (electroporation), was incorporated into a modified Luo-Rudy (L-R) model of ventricular action potentials. In normal myocytes, the pore formation results in a decay of repolarization of the shocked action potential which is followed by prolonged depolarization and oscillation of membrane potential like early after depolarization (EAD). Time- and voltage-dependent changes in delayed-rectifier K/sup +/ current (I/sub k/) in combination with those of L-type Ca/sup 2+/ current (I/sub C/a) and ion flux through the pore (I/sub pore/) are responsible for the prolonged depolarization with EAD-like oscillation of membrane potential. Spontaneous excitation forms the oscillation and depends on an activation of I/sub Ca/. In myocytes of Ca/sup 2+/ overload secondary to 90% inhibition of Na/sup +//K/sup +/ pump, the pore formation results in a delay of repolarization of the shocked action potential, which is followed by slower cyclic depolarization in response to spontaneous release of Ca/sup 2+/ from the sarcoplasmic reticulum (SR). The delay after depolarization (DAD)-type oscillation is abolished by complete block of SR Ca/sup 2+/ release channels. These findings suggest that strong shocks will cause arrhythmogenic responses through a transient rupture of sarcolemma with different subcellular events in ventricular cells under normal and pathological conditions.
File Size	157619
File Format	PDF
ISBN	0780356748
ISSN	1094687X
DOI	10.1109/IEMBS.1999.802183
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	1999-10-13
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Electric shock Analytical models Biomembranes Delay Biological system modeling Strontium Cells (biology) Voltage Muscles Medical simulation
Content Type	Text
Resource Type	Article

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