NDLI: Nitric oxide changes in adult rat brain after transient global ischemia

Content Provider	IEEE Xplore Digital Library
Author	Ghodadra, R. Buerk, D.G. Hao, L. Mohadjer, Y. Thakor, N.V.
Copyright Year	1997
Description	Author affiliation: Dept. of Biomed. Eng., Johns Hopkins Univ., Baltimore, MD, USA (Ghodadra, R.)
Abstract	Nitric oxide (NO), has recently emerged as an important mediator of cellular events which impacts the pathophysiology of cerebral ischemia. Using electrochemical microsensors, we measured the cortical NO concentration within ischemic tissue before and during 3 min. of airway occlusion (asphyxia) and during reperfusion in adult rats (n=6). Baseline concentrations of NO were 1.89/spl plusmn/0.33 /spl mu/M. The maximum concentrations of NO during asphyxia and on reperfusion were 5.15/spl plusmn/0.45 /spl mu/M and 6.50/spl plusmn/0.24 /spl mu/M, respectively. A novel method (cepstral distance) was used to quantify changes in EEG due to brain injury. Our data indicates that excess NO is released in the brain after the onset of ischemia. Its restoration to baseline appears to impact recovery of the brain's electrical function as measured by EEG. Animals (n=2) in which NO did not return to baseline value had isoelectric EEG and showed no sign of recovery.
Starting Page	2151
Ending Page	2152
File Size	214655
Page Count	2
File Format	PDF
ISBN	0780342623
ISSN	1094687X
DOI	10.1109/IEMBS.1997.758780
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	1997-10-30
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Ischemic pain Microsensors Asphyxia Electroencephalography Biomedical engineering Biomedical measurements Rats Cepstral analysis Animals Surgery
Content Type	Text
Resource Type	Article

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