NDLI: New models of phosphate kinetics in dialysis patients

Content Provider	IEEE Xplore Digital Library
Author	Ruggero, A. Giove, S. Nordio, M.
Copyright Year	1997
Description	Author affiliation: Dept. of Electron. & Inf., Padova Univ., Italy (Ruggero, A.)
Abstract	During a dialytic treatment, plasma phosphate (Pi) has a peculiar time course. It reaches a nadir value approximately 90 minutes after the beginning of the treatment and then, despite the ongoing removal, it exhibits either a constant steady state or a slow rebound. In order to quantitatively describe this kinetics, the authors have proposed three different two-compartment models, in which the first compartment represents plasma and extracellular fluids and the second one intra-cellular fluids (IF); to explain the Pi time course, an endogenous release of phosphate must also be present. The models have been identified from a set of data (7 patients). The hypotheses underlying their structure and the identification results were discussed and one model was chosen as the best description of the system, in terms of both mathematical indices and physiological considerations. In this model, the endogenous production of phosphate enters the IF compartment and is dependent on the plasma concentration and on the difference from its initial value. This model was also capable of correctly predicting the qualitative time course of Pi also in the post dialysis period.
Starting Page	2132
Ending Page	2134
File Size	260546
Page Count	3
File Format	PDF
ISBN	0780342623
ISSN	1094687X
DOI	10.1109/IEMBS.1997.758774
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	1997-10-30
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Kinetic theory Steady-state Mathematical model Differential equations Informatics Mathematics Computer science Hospitals Nuclear and plasma sciences Production
Content Type	Text
Resource Type	Article

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