NDLI: Modeling glucose control on endogenous glucose production in nonsteady state: necessity of direct and delayed signalling

Content Provider	IEEE Xplore Digital Library
Author	Simeoni, M. Caumo, A. Rizza, R. Cobelli, C.
Copyright Year	1997
Description	Author affiliation: Dipt. di Elettronica e Inf., Padova Univ., Italy (Simeoni, M.)
Abstract	So far the modalities of glucose control on endogenous glucose production (EGP) under dynamic conditions have been poorly investigated. In the present study we developed models to describe glucose control on EGP under nonsteady-state conditions. The database consisted of experiments during which insulin was maintained at the basal level, glucose concentration exhibited a meal-like profile, and a glucose tracer was infused in such a way to clamp tracer glucose specific activity. This optimal protocol allowed us: (1) to rule out the possibly confounding effect of hyperinsulinemia on the assessment of glucose control on EGP, and (2) to ensure an accurate assessment of the time course of EGP during the nonsteady state. Three models of increasing complexity were formulated, employing different combinations of two modalities of glucose control on EGP, one exerted by glucose in plasma and the other one by glucose in a remote glucose compartment. Each model providing indices measuring glucose inhibitory action on EGP (glucose effectiveness) and the delay of glucose action on EGP. The best model is the one which embodies both direct and delayed glucose control on EGP.
Starting Page	2138
Ending Page	2141
File Size	379546
Page Count	4
File Format	PDF
ISBN	0780342623
ISSN	1094687X
DOI	10.1109/IEMBS.1997.758776
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	1997-10-30
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Sugar Production Plasma measurements Insulin Protocols Pancreas Steady-state Delay Biochemistry Kinetic theory
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in