NDLI: Application of a daily low magnitude mechanical signal reduces adiposity in male mice

Content Provider	IEEE Xplore Digital Library
Author	Luu, Y.K. Capilla, E. Pessin, J.E. Judex, S. Rubin, C.T.
Copyright Year	2007
Description	Author affiliation: State Univ. of New York-Stony Brook, Stony Brook (Luu, Y.K.)
Abstract	The development of obesity and diabetes is often attributable to a sedentary lifestyle, with a common therapeutic intervention being exercise.1 While the presumption has been that more strenuous workouts are more effective in the suppression of adipogenesis, here we show that 15 weeks of brief, daily exposure to high frequency, low magnitude mechanical signals suppresses adipogenesis by 26% in the young adult mouse. Concomitant with this decrease in fat, we observe an increase in both lean volume and bone volume of the animal. Biochemically, this mechanical signal reduces non-esterified free fatty acid and triglyceride content in the liver by 43% and 39%, respectively. The applied signal is induced at a magnitude well below that which would arise during walking and is relatively short in duration. The brevity and low intensity of this mechanical intervention suggests a powerful means of inhibiting the formation of adipose tissue, and subsequently lowering free fatty acid and triglyceride content in several key tissues.
Starting Page	203
Ending Page	204
File Size	271688
Page Count	2
File Format	PDF
ISBN	9781424410323
DOI	10.1109/NEBC.2007.4413349
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2007-03-10
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Mice Animals Liver Torso Bones Vibrations In vivo Protocols Lipidomics Diabetes
Content Type	Text
Resource Type	Article

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