NDLI: Modulation of cardiac electrophysiology by tissue alignment

Content Provider	IEEE Xplore Digital Library
Author	Chung, C. Dasari, V. Bien, H. Entcheva, E.
Copyright Year	2007
Description	Author affiliation: Stony Brook Univ., Stony Brook (Chung, C.)
Abstract	Most cardiac arrhythmias are associated with pathology-triggered ion channel remodeling. However, multicellular effects, e.g. exaggerated anisotropy and altered cell-to-cell coupling, can also indirectly affect action potential morphology and electrical stability via changed electrotonus. Recent computational studies showed that electrotonus affects stability by altering dynamic properties (restitution). Here, we address the question of how cell alignment and connectivity alter function and whether these effects depend on wave propagation direction. We show that cardiac cell arrangement alters electrical stability in an in vitro cardiac tissue model by mechanisms both dependent and independent of wave propagation direction, and local structural remodeling is felt beyond a space constant. Notably, restitution of action potential duration (APD) and conduction velocity were significantly steepened in the direction of cell alignment. Furthermore, prolongation of APD and calcium transient duration was found in highly anisotropic cell networks, in both longitudinal and transverse propagation. This is in contrast to expected correlation between wave propagation direction and APD based on electrotonic effects only, but is consistent with our findings of increased secretion of atrial natriuretic peptide, a hypertrophy marker, in the aligned structures. Our results indicate anisotropic structure is a potent modulator of electrical stability via electrotonus and molecular signaling.
Starting Page	165
Ending Page	166
File Size	1077693
Page Count	2
File Format	PDF
ISBN	9781424410323
DOI	10.1109/NEBC.2007.4413330
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2007-03-10
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Anisotropic magnetoresistance Stability Calcium Cardiac tissue Fluids and secretions Frequency Testing Analysis of variance Biomedical engineering Biochemistry
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
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9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

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