NDLI: Brain region morphological and volumetric quantitative assessment using the 17.6T MRI in rats chronically exposed to methylphenidate

Content Provider	IEEE Xplore Digital Library
Author	Boronikolas, V. Michaelides, M. Wang, G.-J. Blackband, S. Grant, S.C. Metaxas, D. Volkow, N.D. Thanos, P.K.
Copyright Year	2007
Description	Author affiliation: Brookhaven Nat. Lab., Upton (Boronikolas, V.; Michaelides, M.; Wang, G.-J.)
Abstract	Methylphenidate (MPH) is presently the primary pharmacotherapy for the treatment of Attention Deficit Hyperactivity Disorder (ADHD). It has not been determined though what impact long-term treatment with this psychostimulant would have on behavior, neurochemistry or neuroanatomy. Previous studies have shown that the striatum is a major target of MPH treatment, consistent with human MRI studies. Also previous results have shown that long term-exposure to MP in adolescent rats has produced changes in dopamine D2 receptor levels and significantly enhanced cocaine self-administration in adulthood (Thanos et al. 2004). Different animal studies imply that the effects of MPH may depend on the neural responder system whereas structural and functional parameters are improved by MPH in animals with psychomotor impairments, they remain unaltered or get worse in healthy controls. Here we measured the effects of chronic treatment (8 months) with oral MP (1 or 2 mg/kg) or water, which was initiated in adolescent rats (4 weeks old). Following this treatment, rats in adulthood (9 month old) were perfused intracardially and their brains removed and imaged with a 17.6 T MRI for neuroanatomical volume assessment.
Starting Page	43
Ending Page	44
File Size	227047
Page Count	2
File Format	PDF
ISBN	9781424410323
DOI	10.1109/NEBC.2007.4413271
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2007-03-10
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Magnetic resonance imaging Rats Animals Image segmentation Psychology Image resolution Biomedical imaging Pediatrics Shape Neuroimaging
Content Type	Text
Resource Type	Article

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