NDLI: Inducing neuronal bursting activity in the CNS of L. stagnalis using Dimethylformamide

Content Provider	IEEE Xplore Digital Library
Author	Di Cecco, O. Segala, M. Ying Sun
Copyright Year	2007
Description	Author affiliation: Rhode Island Univ., Kingston (Di Cecco, O.)
Abstract	Dimethylformamide (DMF) is a hydrophilic aprotic solvent often used in peptide coupling, an essential process in the pharmaceutical industry. Its use in biological study is typically in the role of a peptide solvent when evaluating the efficacy of peptides and their effect on the cellular membrane. In evaluating the effect of the peptide gramicidin on neurons of the central nervous system (CNS) of the pond snail Lymnaea stagnalis, an interesting cellular response was noted when applying DMF without gramicidin. In the presence of DMF alone, the regular beating pattern of neuron VDI, an identified neuron in the dorsal presentation of the visceral ganglion, changed to bursting pattern. A slight lowering of the membrane potential was also noted.
Starting Page	144
Ending Page	145
File Size	1145140
Page Count	2
File Format	PDF
ISBN	9781424410323
DOI	10.1109/NEBC.2007.4413320
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2007-03-10
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Peptides Neurons Solvents Biomembranes Permeability Central nervous system Kirchhoff's Law Glass Microelectrodes Biology computing
Content Type	Text
Resource Type	Article

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Inducing neuronal bursting activity in the CNS of L. stagnalis using Dimethylformamide