NDLI: Strength-duration curve for an electrically excitable tissue extended down to near 1 nanosecond

Content Provider	IEEE Xplore Digital Library
Author	Rogers, W.R. Merritt, J.H. Comeaux Jr., J.A. Kuhnel, C.T. Moreland, D.F. Teltschik, D.G. Lucas, J.H. Murphy, M.R.
Copyright Year	1973
Abstract	As part of a health and safety assessment of ultrawideband sources, it was useful to determine stimulation thresholds for an electrically excitable tissue down into the low nanosecond range. Stimulation thresholds were measured using gastrocnemius muscles isolated from 16 frogs (Rana sp.). Single pulses were delivered with a pair of surface electrodes, and muscle twitch was measured with an isotonic transducer. Pulse durations of 100, 10, and 1 ms; 100, 10 and 1 /spl mu/s; and 100 and /spl ap/1 ns were used. Tissue voltage and current strength-duration (S-D) curves on log-log plots had a classic appearance, with thresholds for ultrashort pulses being linear. For a pulse of /spl ap/1 ns, the mean threshold voltage in the muscle was 4.5 kV and the mean threshold peak current was 35 A. When delivered by direct contact, a single ultrawideband pulse of /spl ap/1 ns could reliably produce a biological effect, stimulation of an electrically excitable tissue. The observation that the S-D curves extended downward to /spl ap/1 ns in a linear manner suggested that classical ion channel mechanisms regulated excitation and that other processes, such as electroporation, did not occur. Although a single nanosecond pulse delivered by direct contact can elicit a biological response, such a stimulus in air is unlikely to produce an effect.
Sponsorship	IEEE Nuclear and Plasma Sciences Society
Starting Page	1587
Ending Page	1599
Page Count	13
File Size	924201
File Format	PDF
ISSN	00933813
Volume Number	32
Issue Number	4
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2004-08-01
Publisher Place	U.S.A.
Access Restriction	One Nation One Subscription (ONOS)
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Nanobioscience Muscles Ultra wideband technology Pulse measurements Threshold voltage Contacts Health and safety Electrodes Transducers Biological tissues
Content Type	Text
Resource Type	Article
Subject	Nuclear and High Energy Physics Condensed Matter Physics

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