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| Content Provider | IEEE Xplore Digital Library |
|---|---|
| Author | Kyong-Hoon Choi Eun-Wook Choi Jeeeun Min Hyungbin Son Han Sup Uhm Eun HaChoi Bong Joo Park Jin-Seung Jung |
| Copyright Year | 1965 |
| Abstract | In this paper, we have synthesized multifunctional magnetic particles (MNPs) using by two different ferrite submicrometer paticles (Fe3O4@HP and CoFe2O4@HP) with different surface properties. Two different multifunctional particles have the same particle sizes within the error tolerance of 4.5%. The concentration measurement of the hematoporphyrin (HP) molecule indicates that the weight of HP molecules bonded to the surface of the Fe3O4 particles is smaller than that of the CoFe2O4 particles. Moreover, we have evaluated their biocompatibilities and photodynamic anticancer activities on mammalian cells. The two MNPs have demonstrated that they both have good biocompatibilities without any cytotoxicity and anticancer activities in the concentration range of 0-50 μg/mL. Specifically, photodynamic-killing activities of both MNPs were measured to be 100% for CoFe2O4@HP, and were measured to be 37.9 ± 3.5% and 9.2 ± 2.5% for Fe3O4@HP in 25 and 50 μg/mL of both MNPs. These results suggest that both MNPs can be safely used to for clinical photodynamic cancer therapy, although the CoFe2O4@HP showed a slightly better photo-killing efficacy compared with the Fe3O4@HP in prostate cancer. |
| Sponsorship | IEEE Magnetics Society |
| Starting Page | 1 |
| Ending Page | 4 |
| Page Count | 4 |
| File Size | 562929 |
| File Format | |
| ISSN | 00189464 |
| Volume Number | 50 |
| Issue Number | 11 |
| Language | English |
| Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Publisher Date | 2014-01-01 |
| Publisher Place | U.S.A. |
| Access Restriction | One Nation One Subscription (ONOS) |
| Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Subject Keyword | Nanoparticles Ferrites Prostate cancer Magnetic particles Optical surface waves Educational institutions prostate cancer cell Ferrite particle hematoporphyrin (HP) multifunctional magnetic particle (MNP) photodynamic cancer therapy (PDT) |
| Content Type | Text |
| Resource Type | Article |
| Subject | Electronic, Optical and Magnetic Materials Electrical and Electronic Engineering |
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