NDLI: Study and Development of Spacers for Pressurized Inhaler Devices: A Project Review

Content Provider	The American Society of Mechanical Engineers (ASME) Digital Collection
Author	Silva, Lui´s F. Teixeira, Senhorinha Teixeira, Jose´ Carlos Rebelo, Rita Oliveira, Ricardo Antunes, Henedina
Copyright Year	2009
Abstract	In recent years, allergic diseases, particularly asthma, have been acquiring an increasing importance in the developed countries, due to the rising of its prevalence and morbidity and the economic burden associated, becoming a serious public health problem. Recent therapeutic approaches in asthma patients may help to prevent most of the crisis and remain free of symptoms. Several inhalation devices are available for drug delivery to the lungs, including metered-dose inhalers (MDIs), dry powder inhalers (PDIs) and nebulizers. Although this variety of devices used for drug delivery to the bronchial tree have shown encouraging results, a great amount of the drug does not reach the goal and remains in the mouth (less than 20% of the drug can reach the lungs) and higher airways. This causes not only a loss of drug but also increases costs and produces undesirable side effects. For better efficiency of the process, spacers, such as the Volumatic® used in the study herein reported, are used. This paper will describe and summarize part of the developments being carried out so far at the University of Minho in this domain, as well as the latest developments in order to understand the characteristics of the used spacer and the parameters affecting its performance. By using computational fluid Dynamics (CFD) techniques, the behavior of the drug flow inside the spacer, combined with a pressurized metered-dose inhaler (pMDI), the discrete phase model (DPM) flow inside the Volumatic® is also reported. The results obtained are also analyzed and discussed, using two different 3D grid types (Cooper and T-Grid). The insight provided by the detailed data of the flow patterns inside the Volumatic® provides possible options for new geometry possibilities for the spacer devices.
Starting Page	243
Ending Page	247
Page Count	5
File Format	PDF
ISBN	9780791843758
DOI	10.1115/IMECE2009-13171
e-ISBN	9780791838631
Volume Number	Volume 2: Biomedical and Biotechnology Engineering
Conference Proceedings	ASME 2009 International Mechanical Engineering Congress and Exposition
Language	English
Publisher Date	2009-11-13
Publisher Place	Lake Buena Vista, Florida, USA
Access Restriction	Subscribed
Subject Keyword	Volumatic® spacer Respiratory flow Computational fluid dynamics (cfd) Asthma Drugs Geometry Drug delivery systems Computational fluid dynamics Lung Flow (dynamics) Diseases
Content Type	Text
Resource Type	Article

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