NDLI: Effects of Process Parameters on Cell Damage in a 3D Cell Printing Process

Content Provider	The American Society of Mechanical Engineers (ASME) Digital Collection
Author	Yan, Karen Chang Paluch, Kamila Nair, Kalyani Sun, Wei
Copyright Year	2009
Abstract	Various types of bio-fabrication methods have been developed to manufacture products with living cells incorporated via mechanical means. One of fundamental questions that need to be answered is whether cells remain viable and/or functional when subjected to these mechanical disturbances. In this paper, we focus on a 3D cell-printing process via pressure induced deposition. Our experimental studies show that process parameters such as pressure applied and nozzle size affect the cell viability. Given that the cells are suspended in the alginate solution during the printing process, Computational Fluid Dynamic (CFD) analysis is employed to model the pressure-driven flow system and determine the local environment that the living cells are in under varying process parameters. Effects of obtained wall shear stress and exposure time are examined in terms of cell damage based on the corresponding experimental data.
Starting Page	75
Ending Page	81
Page Count	7
File Format	PDF
ISBN	9780791843758
DOI	10.1115/IMECE2009-11528
e-ISBN	9780791838631
Volume Number	Volume 2: Biomedical and Biotechnology Engineering
Conference Proceedings	ASME 2009 International Mechanical Engineering Congress and Exposition
Language	English
Publisher Date	2009-11-13
Publisher Place	Lake Buena Vista, Florida, USA
Access Restriction	Subscribed
Subject Keyword	Printing Computational fluid dynamics Shear stress Nozzles Manufacturing Damage Pressure Flow (dynamics) Biological cells
Content Type	Text
Resource Type	Article

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