NDLI: Analysis of Short Pulse Laser Interaction With Tissues for Tumor Detection

Content Provider	The American Society of Mechanical Engineers (ASME) Digital Collection
Author	Sajjadi, Amir Yousef Pal, Gopalendu Mitra, Kunal Grace, Michael
Copyright Year	2009
Abstract	The objective of the work is to perform both experimental and numerical analysis of short pulse laser interaction with tissue medium with the goal of tumor / cancer diagnostics. Short pulse laser probing techniques for diagnostics have distinct advantages over very large pulse width or continuous wave lasers primarily due to the additional information conveyed by the temporal distribution of the optical signals. For short pulse laser source, the shape of output signal is a function of the optical properties of the medium and hence the scattered optical signal provides information about the medium characteristics. Two laser systems are used: a mode-locked short pulse laser (wavelength = 514 nm and pulsewidth = 200 ps) and a frequency doubled diode short pulse laser (wavelength = 776 nm and pulsewidth = 1.3 ps). The scattered optical signals are measured with a Hamamatsu streak camera. First in vitro experiments are performed on mouse skin tissue samples injected with India ink in order to simulate presence of inhomogeneities. Finally, in vivo imaging is performed on anaesthetized rats with tumorogenic agents injected inside skin tissues and on anaesthetized mouse with mammary tumors. Both the temporal and the spatial profiles of the scattered reflected optical signals are compared with the numerical modeling results obtained by solving the transient radiative transport equation using the discrete ordinates technique. The goal is to demonstrate the feasibility of the time-resolved technique in detecting tumors in animal model.
Starting Page	293
Ending Page	300
Page Count	8
File Format	PDF
ISBN	9780791843758
DOI	10.1115/IMECE2009-11945
e-ISBN	9780791838631
Volume Number	Volume 2: Biomedical and Biotechnology Engineering
Conference Proceedings	ASME 2009 International Mechanical Engineering Congress and Exposition
Language	English
Publisher Date	2009-11-13
Publisher Place	Lake Buena Vista, Florida, USA
Access Restriction	Subscribed
Subject Keyword	Computer simulation Biological tissues Waves Wavelength Inks Transients (dynamics) Numerical analysis Lasers Imaging Skin Signals Shapes Tumors Cancer
Content Type	Text
Resource Type	Article

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