NDLI: Mechanism of Cell Transport in a Microchannel With Binding Between Cell Surface and Immobilized Biomolecules

Content Provider	The American Society of Mechanical Engineers (ASME) Digital Collection
Author	Prashant, R. Waghmare Sushanta, K. Mitra
Copyright Year	2009
Abstract	Recent trends in micro and nano fabrication techniques have opened a new era for microfluidic based immunosensing devices. In immunosensing microfluidic device, the buffer solution transports the different biomolecules and cells. The interaction between the cell and surface of the microchannel takes place during this transport. In the present study, the effect of interaction between the cell and the immobilized biomolecule on the cell transport is analyzed theoretically. A single cell transport is studied with the interaction between the cell surface and the microchannel wall. The type of immobilized biomolecule on the surface and the surface properties of the cell decide the interaction force between cell and biomolecule. In the present analysis, the interaction force between the cell and modified microchannel is considered as a bond force between ligand and receptor. The bond force is equated as an additional rolling friction to investigate the effect of bond force on the cell transport behavior. The coefficient of rolling friction is determined through non-dimensional analysis. The non-dimensional governing equation is solved to investigate the effect of different operation parameters on cell velocity. The cell velocity experiences a resistance while attaining the maximum velocity. This resistance depends on different operating parameters and forces acting on the cell. It is observed that, higher cell density delays the attainment of maximum cell velocity. It is also observed that, the value of maximum cell velocity is function of Reynolds number and bond length. Finally, it is demonstrated that, the bond density and contact area have no effect on the cell velocity behavior beyond the maximum bond density.
Starting Page	779
Ending Page	784
Page Count	6
File Format	PDF
ISBN	9780791843857
DOI	10.1115/IMECE2009-12691
e-ISBN	9780791838631
Volume Number	Volume 12: Micro and Nano Systems, Parts A and B
Conference Proceedings	ASME 2009 International Mechanical Engineering Congress and Exposition
Language	English
Publisher Date	2009-11-13
Publisher Place	Lake Buena Vista, Florida, USA
Access Restriction	Subscribed
Subject Keyword	Cell transport Cell-surface interaction Functionalized surface Rolling friction Nanofabrication Reynolds number Surface properties Delays Polishing equipment Density Microfluidics Microchannels
Content Type	Text
Resource Type	Article

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