NDLI: A SystemC Platform for Signal Transduction Modelling and Simulation in Systems Biology

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A SystemC Platform for Signal Transduction Modelling and Simulation in Systems Biology

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A SystemC Platform for Signal Transduction Modelling and Simulation in Systems Biology

Content Provider	ACM Digital Library
Author	Giugno, Rosalba Distefano, Rosario Laudanna, Carlo Fummi, Franco Bombieri, Nicola
Abstract	Signal transduction is a class of cell's biological processes, which are commonly represented as highly concurrent reactive systems. In the Systems Biology community, modelling and simulation of signal transduction require overcoming issues like discrete event-based execution of complex systems, description from building blocks through composition and encapsulation, description at different levels of granularity, methods for abstraction and refinement. This paper presents a signal transduction modelling and simulation platform based on SystemC, and shows how the platform allows handling the system complexity by modelling it at different abstraction levels. The paper reports the results obtained by applying the platform to model the intracellular signalling network controlling integrin activation mediating leukocyte recruitment from the blood into the tissues.
Starting Page	233
Ending Page	236
Page Count	4
File Format	PDF
ISBN	9781450334747
DOI	10.1145/2742060.2742115
Language	English
Publisher	Association for Computing Machinery (ACM)
Publisher Date	2015-05-20
Publisher Place	New York
Access Restriction	Subscribed
Subject Keyword	Signal transduction Modeling and simulation Systemc
Content Type	Text
Resource Type	Article

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