NDLI: The Src kinase Lck facilitates assembly of HIV-1 at the plasma membrane.

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The Src kinase Lck facilitates assembly of HIV-1 at the plasma membrane.

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The Src kinase Lck facilitates assembly of HIV-1 at the plasma membrane.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Strasner, Amy B. August, Avery Key, Douglas Henderson, Andrew J. Natarajan, Malini Doman, Tom
Description	Country affiliation: United States Author Affiliation: Strasner AB ( Intergrated Bioscience Program in Immunobiology, Huck Institute of the Life Sciences, Pennsylvania State University, University Park, PA 16802, USA.)
Abstract	HIV type 1 (HIV-1) assembly and egress are driven by the viral protein Gag and occur at the plasma membrane in T cells. Recent evidence indicates that secretory vesicles and machinery are essential components of virus packaging in both T cells and macrophages. However, the pathways and cellular mediators of Gag targeting to the plasma membrane are not well characterized. Lck, a lymphoid specific Src kinase critical for T cell activation, is found in the plasma membrane as well as various intracellular compartments and it has been suggested to influence HIV-1 replication. To investigate Lck as a potential regulator of Gag targeting, we assessed HIV-1 replication and Gag-induced virus-like particle release in the presence and absence of Lck. Release of HIV-1 and virus-like particles was reduced in the absence of Lck. This decrease in replication was not due to altered HIV-1 infection, transcription or protein translation. However, in T cells lacking Lck, HIV-1 accumulated intracellularly. In addition, expressing Lck in HeLa cells promoted HIV-1 Gag plasma membrane localization. Palmitoylation of the Lck unique domain, which is essential for directing Lck to the plasma membrane, was critical for its effect on HIV-1 replication. Furthermore, HIV-1 Gag directly interacted with the Lck unique domain in the context of infected cells. These results indicate that Lck plays a key role in targeting HIV-1 Gag to the plasma membrane in T cells.
ISSN	00221767
e-ISSN	15506606
Journal	The Journal of Immunology
Issue Number	5
Volume Number	181
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2008-09-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Cell Membrane Virology Hiv-1 Physiology Lymphocyte Specific Protein Tyrosine Kinase P56(lck) Virus Assembly Jurkat Cells Metabolism T-lymphocytes Gag Gene Products, Human Immunodeficiency Virus Research Support, N.i.h., Extramural Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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Combined Env- and Gag-specific T cell responses in relation to programmed death-1 receptor and CD4 T cell loss rates in human immunodeficiency virus-1 infection.

Plasma membrane subdomain partitioning of Lck in primary human T lymphocytes.

Focal adhesion kinase negatively regulates Lck function downstream of the T cell antigen receptor.

HIV Nef expression favors the relative preservation of CD4+ T regulatory cells that retain some important suppressive functions.

Evaluating potential T-cell epitope peptides for detecting HIV-specific T cell responses in a highly diverse HIV-1 epidemic from Cameroon.

The Src Kinase Lck Facilitates Assembly of HIV-1 at the Plasma Membrane1

Distinct kinetics of Gag-specific CD4+ and CD8+ T cell responses during acute HIV-1 infection.

HIV-1 evolution in gag and env is highly correlated but exhibits different relationships with viral load and the immune response.

Fine-tuning of T-cell receptor avidity to increase HIV epitope variant recognition by cytotoxic T lymphocytes.

The Src kinase Lck facilitates assembly of HIV-1 at the plasma membrane.

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The Src kinase Lck facilitates assembly of HIV-1 at the plasma membrane.