NDLI: Neutrophil Apoptosis: Selective Regulation by Different Ligands of Integrin $α_{M}β_{2}$

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Neutrophil Apoptosis: Selective Regulation by Different Ligands of Integrin $α_{M}β_{2}$

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Neutrophil Apoptosis: Selective Regulation by Different Ligands of Integrin $α_{M}β_{2}$

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Weber, Christian Szpak, Dorota Pluskota, Elzbieta Soloviev, Dmitry A. Plow, Edward F.
Description	Country affiliation: United States Author Affiliation: Pluskota E ( Joseph J. Jacobs Center for Thrombosis and Vascular Biology, Department of Molecular Cardiology, Cleveland Clinic Foundation, Cleveland, OH 44195, USA.)
Abstract	Neutrophils undergo spontaneous apoptosis, but their survival can be extended during inflammatory responses. alpha(M)beta(2) is reported either to delay or accelerate neutrophil apoptosis, but the mechanisms by which this integrin can support such diametrically opposed responses are poorly understood. The abilities of closely related alpha(M)beta(2) ligands, plasminogen and angiostatin, derived from plasminogen, as well as fibrinogen and its two derivative alpha(M)beta(2) recognition peptides, P1 and P2-C, differed markedly in their effects on neutrophil apoptosis. Plasminogen, fibrinogen, and P2-C suppressed apoptosis via activation of Akt and ERK1/2 kinases, while angiostatin and P1 failed to activate these prosurvival pathways and did not prevent neutrophil apoptosis. Using cells transfected with alpha(M)beta(2) or its individual alpha(M) or beta(2) subunits, and purified receptors and its constituent chains, we show that engagement of both subunits with prosurvival ligands is essential for induction of the prosurvival response. Hence, engagement of a single integrin by closely related ligands can induce distinct signaling pathways, which can elicit distinct cellular responses.
ISSN	00221767
e-ISSN	15506606
Journal	The Journal of Immunology
Issue Number	5
Volume Number	181
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2008-09-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Apoptosis Macrophage-1 Antigen Physiology Neutrophils Cytology Angiostatins Cells, Cultured Fibrinogen K562 Cells Ligands Plasminogen Protein Subunits Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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