NDLI: Anergy in Memory $CD4^{+}$ T Cells Is Induced by B Cells

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Anergy in Memory $CD4^{+}$ T Cells Is Induced by B Cells

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Anergy in Memory $CD4^{+}$ T Cells Is Induced by B Cells

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Morrot, Alexandre Dalai, Sarat K. Mirshahidi, Saied Zavala, Fidel Sadegh-Nasseri, Scheherazade
Description	Country affiliation: United States Author Affiliation: Dalai SK ( Department of Pathology, Johns Hopkins School of Medicine, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore MD 21205, USA.)
Abstract	Induction of tolerance in memory T cells has profound implications in the treatment of autoimmune diseases and transplant rejection. Previously, we reported that the presentation of low densities of agonist peptide/MHC class II complexes induced anergy in memory CD4(+) T cells. In the present study, we address the specific interaction of different types of APCs with memory CD4(+) T cells. A novel ex vivo anergy assay first suggested that B cells induce anergy in memory T cells, and an in vivo cell transfer assay further confirmed those observations. We demonstrated that B cells pulsed with defined doses of Ag anergize memory CD4 cells in vivo. We established that CD11c(+) dendritic cells do not contribute to anergy induction to CD4 memory T cells, because diphtheria toxin receptor-transgenic mice that were conditionally depleted of dendritic cells optimally induced anergy in memory CD4(+) T cells. Moreover, B cell-deficient muMT mice did not induce anergy in memory T cells. We showed that B2 follicular B cells are the specific subpopulation of B cells that render memory T cells anergic. Furthermore, we present data showing that anergy in this system is mediated by CTLA-4 up-regulation on T cells. This is the first study to demonstrate formally that B cells are the APCs that induce anergy in memory CD4(+) T cells.
ISSN	00221767
e-ISSN	15506606
Journal	The Journal of Immunology
Issue Number	5
Volume Number	181
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2008-09-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	B-lymphocytes Physiology Cd4-positive T-lymphocytes Clonal Anergy Immunology Immunologic Memory Animals Antigen-presenting Cells Antigens, Cd Genetics Ctla-4 Antigen Coculture Techniques Mice Up-regulation Research Support, N.i.h., Extramural Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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