NDLI: Lipopolysaccharide is a direct agonist for platelet RNA splicing.

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Lipopolysaccharide is a direct agonist for platelet RNA splicing.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Marathe, Gopal K. Brown, G. Thomas McIntyre, Thomas M. Ghosh, Arundhati Shashkin, Pavel N.
Description	Country affiliation: United States Author Affiliation: Shashkin PN ( Department of Cell Biology, Lerner Research Institute, Cleveland Clinic Lerner College of Medicine, Cleveland, OH 44195, USA.)
Abstract	Platelets express TLR4 receptors, but its ligand LPS does not directly activate thrombotic functions nor, obviously, transcription by these anucleate cells. Platelets, however, store information that changes their phenotype over a few hours in the form of unprocessed RNA transcripts. We show even low concentrations of LPS in the presence of soluble CD14 initiated splicing of unprocessed IL-1beta RNA, with translation and accumulation of IL-1beta protein. LPS was a more robust agonist for this response than thrombin. Platelets also contained cyclooxygenase-2 pre-mRNA, which also was spliced and translated after LPS stimulation. Flow cytometry and immunocytochemistry of platelets extensively purified by negative immunodepletion showed platelets contained IL-1beta, and quantitative assessment of white blood cell contamination by CD14 real time PCR confirms that leukocytes were not the IL-1beta source, nor were they required for platelet stimulation. LPS did not initiate rapid platelet responses, but over time did prime platelet aggregation to soluble agonists, induced actin rearrangement, and initiated granule secretion with P-selectin expression that resulted the coating of quiescent leukocytes with activated platelets. LPS is a direct agonist for platelets that allows these cells to directly participate in the innate immune response to bacteria.
ISSN	00221767
e-ISSN	15506606
Journal	The Journal of Immunology
Issue Number	5
Volume Number	181
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2008-09-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Blood Platelets Drug Effects Cyclooxygenase 2 Genetics Interleukin-1beta Lipopolysaccharides Pharmacology Rna Splicing Metabolism Cell Adhesion Cells, Cultured Leukocytes Platelet Activation Platelet Aggregation Rna, Messenger Research Support, N.i.h., Extramural Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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