NDLI: Gene expression profiling in autoimmune noninfectious uveitis disease.

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Gene expression profiling in autoimmune noninfectious uveitis disease.

Year: 2008 Volume: 181 Issue: 6

Year: 2008 Volume: 181 Issue: 5

Year: 2008 Volume: 181 Issue: 4

Year: 2008 Volume: 181 Issue: 3

Year: 2008 Volume: 181 Issue: 2

Gene expression profiling in autoimmune noninfectious uveitis disease.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Sen, H. Nida Mahesh, Sankaranarayana P. Yeh, Steven Buggage, Ronald Liu, Baoying Clarke, Grace Miller, Sheldon S. Lew, Julie Li, Zhuqing Lim, Wee Kiak Nussenblatt, Robert B. Maminishkis, Arvydas
Description	Country affiliation: United States Author Affiliation: Li Z ( Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA.)
Abstract	Noninfectious uveitis is a predominantly T cell-mediated autoimmune, intraocular inflammatory disease. To characterize the gene expression profile from patients with noninfectious uveitis, PBMCs were isolated from 50 patients with clinically characterized noninfectious uveitis syndrome. A pathway-specific cDNA microarray was used for gene expression profiling and real-time PCR array for further confirmation. Sixty-seven inflammation- and autoimmune-associated genes were found differentially expressed in uveitis patients, with 28 of those genes being validated by real-time PCR. Several genes previously unknown for autoimmune uveitis, including IL-22, IL-19, IL-20, and IL-25/IL-17E, were found to be highly expressed among uveitis patients compared with the normal subjects with IL-22 expression highly variable among the patients. Furthermore, we show that IL-22 can affect primary human retinal pigment epithelial cells by decreasing total tissue resistance and inducing apoptosis possibly by decreasing phospho-Bad level. In addition, the microarray data identified a possible uveitis-associated gene expression pattern, showed distinct gene expression profiles in patients during periods of clinical activity and quiescence, and demonstrated similar expression patterns in related patients with similar clinical phenotypes. Our data provide the first evidence that a subset of IL-10 family genes are implicated in noninfectious uveitis and that IL-22 can affect human retinal pigment epithelial cells. The results may facilitate further understanding of the molecular mechanisms of autoimmune uveitis and other autoimmune originated inflammatory diseases.
ISSN	00221767
e-ISSN	15506606
Journal	The Journal of Immunology
Issue Number	7
Volume Number	181
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2008-10-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Autoimmune Diseases Genetics Immunology Gene Expression Profiling Gene Expression Regulation Uveitis Adolescent Metabolism Cells, Cultured Oligonucleotide Array Sequence Analysis Retinal Pigment Epithelium Cytology Signal Transduction Comparative Study Research Support, N.i.h., Intramural Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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