NDLI: Intrinsic and induced regulation of the age-associated onset of spontaneous experimental autoimmune encephalomyelitis.

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Year: 2008 Volume: 181 Issue: 6

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Year: 2008 Volume: 181 Issue: 4

Year: 2008 Volume: 181 Issue: 3

Year: 2008 Volume: 181 Issue: 2

Intrinsic and induced regulation of the age-associated onset of spontaneous experimental autoimmune encephalomyelitis.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Zhang, Hong Podojil, Joseph R. Miller, Stephen D. Luo, Xunrong
Description	Country affiliation: United States Author Affiliation: Zhang H ( Department of Microbiology-Immunology and the Interdepartmental Immunobiology Center, Northwestern University, Chicago, IL 60611, USA.)
Abstract	Multiple sclerosis is characterized by perivascular CNS infiltration of myelin-specific CD4(+) T cells and activated mononuclear cells. TCR transgenic mice on the SJL background specific for proteolipid protein (PLP)(139-151) develop a high incidence of spontaneous experimental autoimmune encephalomyelitis (sEAE). We examined the intrinsic mechanisms regulating onset and severity of sEAE. CD4(+) T cells isolated from the cervical lymph nodes, but not spleens, of diseased 5B6 transgenic mice are hyperactivated when compared with age-matched healthy mice and produce both IFN-gamma and IL-17, indicating that the cervical lymph node is the initial peripheral activation site. The age-associated development of sEAE correlates with a decline in both the functional capacity of natural regulatory T cells (nTregs) and in PLP(139-151)-induced IL-10 production and a concomitant increase in IL-17 production. Anti-CD25-induced inactivation of nTregs increased the incidence and severity of sEAE. Conversely, induction of peripheral tolerance via the i.v. injection of PLP(139-151)-pulsed, ethylcarbodiimide-fixed APCs (PLP(139-151)-SP) inhibited the development of clinical disease concomitant with increased production of IL-10 and conversion of Foxp3(+) Tregs from CD4(+)CD25(-) progenitors. These data indicate that heterogeneous populations of Tregs regulate onset of sEAE, and that induction of peripheral tolerance can be exploited to prevent/treat spontaneous autoimmune disease.
ISSN	00221767
e-ISSN	15506606
Journal	The Journal of Immunology
Issue Number	7
Volume Number	181
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2008-10-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Aging Immunology Encephalomyelitis, Autoimmune, Experimental Physiopathology Genetics Amino Acid Sequence Animals Cells, Cultured Crosses, Genetic Prevention & Control Genetic Predisposition To Disease Immune Tolerance Mice Mice, Inbred C57bl Mice, Inbred Strains Mice, Transgenic Molecular Sequence Data Myelin Proteolipid Protein Administration & Dosage Peptide Fragments Severity Of Illness Index Time Factors Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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