NDLI: Transplantation Survival Is Maintained by Granzyme $B^{+}$ Regulatory Cells and Adaptive Regulatory T Cells

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Transplantation Survival Is Maintained by Granzyme $B^{+}$ Regulatory Cells and Adaptive Regulatory T Cells

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Transplantation Survival Is Maintained by Granzyme $B^{+}$ Regulatory Cells and Adaptive Regulatory T Cells

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Gondek, David C. Devries, Victor Scott, Zachary A. Noelle, Randolph J. Nowak, Elizabeth C. Lu, Li-Fan Bennett, Kathryn A.
Description	Country affiliation: United States Author Affiliation: Gondek DC ( Department of Microbiology and Immunology, Dartmouth Medical School and Norris Cotton Cancer Center, Lebanon, NH 03756, USA.)
Abstract	Granzyme B (GZB) has been implicated as an effector mechanism in regulatory T cells (T(reg)) suppression. In a model of T(reg)-dependent graft tolerance, it is shown that GZB- deficient mice are unable to establish long-term tolerance. Moreover, mice overexpressing the inhibitor of GZB, serine protease inhibitor 6, are also resistant to tolerization to alloantigen. Graft survival was shorter in bone marrow-mixed chimeras reconstituted with GZB-deficient T(reg) as compared with wild-type T(reg). Whereas there was no difference in graft survival in mixed chimeras reconstituted with wild-type, perforin-deficient, or Fas ligand-deficient T(reg). Finally, data also show that if alloreactive effectors cannot express FoxP3 and be induced to convert in the presence of competent T(reg), then graft tolerance is lost. Our data are the first in vivo data to implicate GZB expression by T(reg) in sustaining long-lived graft survival.
ISSN	00221767
e-ISSN	15506606
Journal	The Journal of Immunology
Issue Number	7
Volume Number	181
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2008-10-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Graft Survival Immunology Granzymes Biosynthesis Physiology Skin Transplantation T-lymphocytes, Regulatory Enzymology Amino Acid Sequence Animals Bone Marrow Transplantation Cells, Cultured Coculture Techniques Forkhead Transcription Factors Genetics Deficiency Immunity, Innate Membrane Proteins Mice Mice, Inbred Balb C Mice, Inbred C57bl Mice, Knockout Mice, Mutant Strains Mice, Transgenic Molecular Sequence Data Serine Endopeptidases Serpins Pathology Transplantation Tolerance Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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Serine protease inhibitor 6 plays a critical role in protecting murine granzyme B-producing regulatory T cells.

Serine protease inhibitor-6 inhibits granzyme B-mediated injury of renal tubular cells and promotes renal allograft survival.

Spontaneous Allograft Tolerance in B7-Deficient Mice Independent of Preexisting Endogenous CD4+CD25+ Regulatory T-Cells

'Default' generation of neonatal regulatory T cells.

CD8+ Foxp3+ regulatory T cells are induced during graft-versus-host disease and mitigate disease severity.

Deletion of CD98 heavy chain in T cells results in cardiac allograft acceptance by increasing regulatory T cells.

Recipient type-specific engineered regulatory T cells prevent graft-vs-host disease after allogeneic bone marrow transplantation in mice.

Foxp3-expressing sensitized Teff cells prolong survival of corneal allograft in corneal allograft transplantation mouse model.

HY-Specific Induced Regulatory T Cells Display High Specificity and Efficacy in the Prevention of Acute Graft-versus-Host Disease.

Transplantation Survival Is Maintained by Granzyme $B^{+}$ Regulatory Cells and Adaptive Regulatory T Cells

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Serine protease inhibitor 6 plays a critical role in protecting murine granzyme B-producing regulatory T cells.

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Transplantation Survival Is Maintained by Granzyme $B^{+}$ Regulatory Cells and Adaptive Regulatory T Cells