NDLI: Bone marrow precursor cells from aged mice generate CD4 T cells that function well in primary and memory responses.

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Bone marrow precursor cells from aged mice generate CD4 T cells that function well in primary and memory responses.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Maue, Alexander C. Eaton, Sheri M. Swain, Susan L. Haynes, Laura
Description	Country affiliation: United States Author Affiliation: Eaton SM ( Trudeau Institute, Saranac Lake, NY 12983, USA.)
Abstract	Understanding how aging impacts the function of memory CD4 T cells is critical for designing effective vaccines. Our studies show that immunological memory generated during youth functions well into old age, whereas that generated later in life functions poorly. This is the result of declines in the function of naive CD4 T cells from aged individuals and contributes to reduced efficacy of vaccines in the elderly. To begin to identify the cause of this defect, we examined the function of memory T cells generated from bone marrow precursor cells (BMPC) from young or aged mice in young hosts. In two different models, memory cells derived from young and aged BMPC exhibit good ex vivo and in vivo function. Importantly, memory CD4 T cells generated from aged BMPC exhibit potent cognate helper function for humoral responses, which are critical for effective immunization. These results indicate that there are no apparent age-related intrinsic defects in BMPC with regards to generation of functional memory T cells.
ISSN	00221767
e-ISSN	15506606
Journal	The Journal of Immunology
Issue Number	7
Volume Number	181
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2008-10-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Aging Immunology Bone Marrow Cells Cd4-positive T-lymphocytes Cell Differentiation Immunologic Memory Stem Cells Genetics Animals Cytology Metabolism Bone Marrow Transplantation Cell Line Cells, Cultured Immunophenotyping Mice Mice, Congenic Mice, Inbred C57bl Mice, Transgenic Radiation Chimera Receptors, Antigen, T-cell Physiology G0 Phase Stem Cell Transplantation Comparative Study Research Support, N.i.h., Extramural Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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Distinct cell types control lymphoid subset development by means of IL-15 and IL-15 receptor alpha expression.

Type II membrane protein CD69 regulates the formation of resting T-helper memory.

Helping themselves: optimal virus-specific CD4 T cell responses require help via CD4 T cell licensing of dendritic cells.

Class II-positive hematopoietic cells cannot mediate positive selection of CD4+ T lymphocytes in class II-deficient mice.

Bone marrow precursor cells from aged mice generate CD4 T cells that function well in primary and memory responses.

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