NDLI: Comparison of biological activity of human anti-apical membrane antigen-1 antibodies induced by natural infection and vaccination.

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Comparison of biological activity of human anti-apical membrane antigen-1 antibodies induced by natural infection and vaccination.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Diouf, Ababacar Diemert, David Mullen, Gregory E. D. Long, Carole A. Miller, Louis H. Miura, Kazutoyo Zhou, Hong Malkin, Elissa Thera, Mahamadou A. Dolo, Amagana Moretz, Samuel E. Doumbo, Ogobara
Spatial Coverage	United States Mali
Description	Country affiliation: United States Author Affiliation: Miura K ( Malaria Vaccine Development Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.)
Abstract	Vaccines represent a significant potential means of decreasing global morbidity and mortality due to malaria. Clinical trials in the United States with Plasmodium falciparum Apical Membrane Antigen 1 (AMA1) showed that the vaccine induced biologically active Abs judged by an in vitro parasite growth inhibition assay (GIA). However, the same vaccine in Malian adults did not increase biological activity, although it elevated ELISA titers. Because GIA has been used to evaluate the biological activity of Abs induced by blood stage malarial vaccine candidates, we explored this discrepancy in this study. We affinity purified AMA1-specific Abs from both U.S. vaccinees and nonvaccinated individuals living in a malaria-endemic area of Mali and performed ELISA and GIA. Both AMA1-specifc Abs induced by vaccination (U.S.) and by natural infection (Mali) have comparable biological activity in GIA when the ELISA titer is normalized. However, a fraction of Malians' IgG that did not bind to AMA1 protein (Mali-non-AMA1 IgG) reduced the biological activity of the AMA1 Abs from U.S. vaccinees; in contrast, U.S.-non-AMA1 IgGs did not show a reduction of the biological activity. Further investigation revealed that the reduction was due to malaria-specific IgGs in the Mali-non-AMA1 IgGs. The fact that both U.S.- and Mali-AMA1-specific Abs showed comparable biological activity supports further development of AMA1-based vaccines. However, the reduction of biological activity of AMA1-specific Ab by other malaria-specific IgGs likely explains the limited effect on growth-inhibitory activity of Abs induced by AMA1 vaccination in Malian adults and may complicate efforts to develop a blood stage malaria vaccine.
ISSN	00221767
e-ISSN	15506606
Journal	The Journal of Immunology
Issue Number	12
Volume Number	181
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2008-12-15
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Antibodies, Protozoan Metabolism Antigens, Protozoan Immunology Malaria Vaccines Malaria, Falciparum Epidemiology Membrane Proteins Protozoan Proteins Adolescent Animals Biosynthesis Blood Child, Preschool Cross-sectional Studies Immunity, Innate Immunoglobulin G Infant Longitudinal Studies Administration & Dosage Parasitology Mali Plasmodium Falciparum Growth & Development Single-blind Method Clinical Trial, Phase I Comparative Study Multicenter Study Randomized Controlled Trial Research Support, N.i.h., Intramural Research Support, Non-u.s. Gov't Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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