NDLI: Preferential use of DH reading frame 2 alters B cell development and antigen-specific antibody production.

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Preferential use of DH reading frame 2 alters B cell development and antigen-specific antibody production.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Zemlin, Michael Zhuang, Yingxin Kobayashi, Ryoki Fujihashi, Kohtaro Rajewsky, Klaus Gartland, G. Larry Schelonka, Robert L. Szalai, Alex Ippolito, Gregory C. Schroeder, Harry W.
Description	Country affiliation: United States Author Affiliation: Schelonka RL ( Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.)
Abstract	All jawed vertebrates limit use of D(H) reading frames (RFs) that are enriched for hydrophobic amino acids. In BALB/c mice, DFL16.1 RF2 encodes valine and isoleucine. To test whether increased use of RF2 affects B cell function, we examined B cell development and Ab production in mice with an IgH allele (DeltaD-DmicroFS) limited to use of a single, frameshifted DFL61.1 gene segment. We compared the results of these studies to wild-type mice, as well as those previously obtained in mice limited to use of either a single normal D(H) or a single inverted D(H) that forces use of arginine in CDR-H3. All three of the mouse strains limited to a single D(H) produced fewer immature B cells than wild type. However, whereas mice limited to a single normal D(H) achieved normal B cell numbers in the periphery, mice forced to preferentially use RF2 had reduced numbers of mature B cells in the spleen and bone marrow, mirroring the pattern previously observed in mice enriched for charged CDR-H3s. There were two exceptions. B cells in the mice using RF2 normally populated the marginal zone and peritoneal cavity, whereas mice using inverted RF1 had increased numbers of marginal zone B cells and decreased numbers of B1a cells. When challenged with several T-dependent or T-independent Ags, Ag-specific Ab titers in the mice forced to use RF2 were altered. These findings indicate that B cell development and Ag-specific Ab production can be heavily influenced by the global amino acid content of the CDR-H3 repertoire.
ISSN	00221767
e-ISSN	15506606
Journal	The Journal of Immunology
Issue Number	12
Volume Number	181
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2008-12-15
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Antibody Diversity Genetics B-lymphocyte Subsets Immunology Pathology Cell Differentiation Epitopes, B-lymphocyte Gene Rearrangement, B-lymphocyte, Heavy Chain Immunoglobulin Heavy Chains Biosynthesis Reading Frames Animals Metabolism Complementarity Determining Regions Frameshift Mutation Mice Mice, Inbred Balb C Mice, Mutant Strains Comparative Study Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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