NDLI: Rapid appearance of resolvin precursors in inflammatory exudates: novel mechanisms in resolution.

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Rapid appearance of resolvin precursors in inflammatory exudates: novel mechanisms in resolution.

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Rapid appearance of resolvin precursors in inflammatory exudates: novel mechanisms in resolution.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Yang, Rong Porter, Timothy F. Petasis, Nicos A. Agrawal, Nitin Irimia, Daniel Toner, Mehmet Kasuga, Kie Serhan, Charles N.
Description	Country affiliation: United States Author Affiliation: Kasuga K ( Department of Anesthesiology, Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women's Hospital, Boston, MA 02115, USA.)
Abstract	Resolution of inflammation is essential. Although supplementation of omega-3 fatty acids is widely used, their availability at sites of inflammation is not known. To this end, a multidisciplinary approach was taken to determine the relationship of circulating omega-3 to inflammatory exudates and the generation of resolution signals. In this study, we monitored resolvin precursors in evolving exudates, which initially paralleled increases in edema and infiltrating neutrophils. We also prepared novel microfluidic chambers to capture neutrophils from a drop of blood within minutes that permitted single-cell monitoring. In these, docosahexaenoic acid-derived resolvin D1 rapidly stopped neutrophil migration, whereas precursor docosahexaenoic acid did not. In second organ injury via ischemia-reperfusion, resolvin metabolically stable analogues were potent organ protectors reducing neutrophils. Together, these results indicate that circulating omega-3 fatty acids rapidly appear in inflammatory sites that require conversion to resolvins that control excessive neutrophil infiltration, protect organs, and foster resolution.
ISSN	00221767
e-ISSN	15506606
Journal	The Journal of Immunology
Issue Number	12
Volume Number	181
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2008-12-15
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Ascitic Fluid Metabolism Pathology Docosahexaenoic Acids Eicosapentaenoic Acid Analogs & Derivatives Exudates And Transudates Inflammation Mediators Animals Anti-inflammatory Agents, Non-steroidal Administration & Dosage Blood Immunology Cell Migration Inhibition Diffusion Chambers, Culture Chemistry Fatty Acids, Omega-3 Mice Mice, Inbred Strains Neutrophils Peritonitis Time Factors Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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