NDLI: Mucosal Humoral Immune Response to SIVmac239∆nef Vaccination and Vaginal Challenge.

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Mucosal Humoral Immune Response to SIVmac239∆nef Vaccination and Vaginal Challenge.

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Mucosal Humoral Immune Response to SIVmac239∆nef Vaccination and Vaginal Challenge.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Carlis, John V. Smith, Anthony J. Lifson, Jeffrey D. Haase, Ashley T. Voss, James E. Wietgrefe, Stephen W. Shang, Liang Johnson, R. Paul Zeng, Ming Piatak, Michael Li, Qingsheng
Description	Author Affiliation: Zeng M ( Department of Microbiology and Immunology, Medical School, University of Minnesota, Minneapolis, MN 55455); Smith AJ ( Department of Microbiology and Immunology, Medical School, University of Minnesota, Minneapolis, MN 55455); Shang L ( Department of Microbiology and Immunology, Medical School, University of Minnesota, Minneapolis, MN 55455); Wietgrefe SW ( Department of Microbiology and Immunology, Medical School, University of Minnesota, Minneapolis, MN 55455); Voss JE ( Department of Immunology and Microbial Science, International AIDS Vaccine Initiative Neutralizing Antibody Center, Center for HIV/AIDS Vaccine Immunology and Immunogen Design, The Scripps Research Institute, La Jolla, CA 92037); Carlis JV ( Department of Computer Science and Engineering, College of Science and Engineering, University of Minnesota, Minneapolis, MN 55455); Li Q ( Department of Microbiology and Immunology, Medical School, University of Minnesota, Minneapolis, MN 55455); Piatak M ( AIDS and Cancer Virus Program, Science Applications International Corporation-Frederick, Inc., National Cancer Institute, Frederick, MD 21702); Lifson JD ( AIDS and Cancer Virus Program, Science Applications International Corporation-Frederick, Inc., National Cancer Institute, Frederick, MD 21702); Johnson RP ( New England Primate Research Center, Harvard Medical School, Southborough, MA, 01772); Haase AT ( Department of Microbiology and Immunology, Medical School, University of Minnesota, Minneapolis, MN 55455)
Abstract	Live attenuated vaccines such as SIV with a deleted nef gene have provided the most robust protection against subsequent vaginal challenge with wild-type (WT) SIV in the SIV-rhesus macaque model of HIV-1 transmission to women. Hence, identifying correlates of this protection could enable design of an effective HIV-1 vaccine. One such prechallenge correlate of protection from vaginal challenge has recently been identified as a system with three components: 1) IgG Abs reacting with the viral envelope glycoprotein trimeric gp41; 2) produced by plasma cells in the submucosa and ectopic tertiary lymphoid follicles in the ectocervix and vagina; and 3) concentrated on the path of virus entry by the neonatal FcR in the overlying epithelium. We now examine the mucosal production of the Ab component of this system after vaginal challenge. We show that vaginal challenge immediately elicits striking increases in plasma cells not only in the female reproductive tract but also at other mucosal sites, and that these increases correlate with low but persistent replication at mucosal sites. We describe vaginal ectopic follicles that are structurally and functionally organized similar to follicles in secondary lymphoid organs, and we provide inferential evidence for a key role of the female reproductive tract epithelium in facilitating Ab production, affinity maturation, and class switch recombination. Vaccination thus accesses an epithelial-immune system axis in the female reproductive tract to respond to exposure to mucosal pathogens. Designing strategies to mimic this system could advance development of an effective HIV-1 vaccine.
ISSN	00221767
e-ISSN	15506606
Journal	The Journal of Immunology
Issue Number	6
Volume Number	196
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2016-03-15
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Aids Vaccines Immunology Epithelium Metabolism Hiv Infections Hiv-1 Physiology Simian Acquired Immunodeficiency Syndrome Simian Immunodeficiency Virus Vagina Animals Antibodies, Viral Hiv Envelope Protein Gp41 Histocompatibility Antigens Class I Immunity, Humoral Immunity, Mucosal Immunization Macaca Mulatta Receptors, Fc Vaccines, Attenuated Virus Internalization Virus Replication Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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