NDLI: Loss of B7-H1 expression by recipient parenchymal cells leads to expansion of infiltrating donor CD8+ T cells and persistence of graft-versus-host disease.

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Loss of B7-H1 expression by recipient parenchymal cells leads to expansion of infiltrating donor CD8+ T cells and persistence of graft-versus-host disease.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Wang, Miao Huang, Wendong Martin, Paul Deng, Ruishu Zeng, Defu Chen, Lieping Li, Xiaofan Liu, Can Young, James Du, Chantal Chen, Yuanzhong Meng, Zhipeng He, Wei Forman, Stephen
Description	Country affiliation: United States Author Affiliation: Li X ( Beckman Research Institute, City of Hope National Medical Center, Duarte, CA 91010, USA.)
Abstract	Previous experimental studies have shown that acute graft-versus-host disease (GVHD) is associated with two waves of donor CD8(+) T cell expansion. In the current studies, we used in vivo bioluminescent imaging, in vivo BrdU labeling, and three different experimental GVHD systems to show that B7-H1 expression by recipient parenchymal cells controls the second wave of alloreactive donor CD8(+) T cell expansion and the associated second phase of GVHD. Loss of B7-H1 expression by parenchymal cells during the course of GVHD was associated with persistent proliferation of donor CD8(+) T cells in GVHD target tissues and continued tissue injury, whereas persistent expression of B7-H1 expression by parenchymal cells led to reduced proliferation of donor CD8(+) T cells in GVHD target tissues and resolution of GVHD. These studies demonstrate that parenchymal cell expression of B7-H1 is required for tolerizing infiltrating T cells and preventing the persistence of GVHD. Our results suggest that therapies designed to preserve or restore expression of B7-H1 expression by parenchymal tissues in the recipient could prevent or ameliorate GVHD in humans.
ISSN	00221767
e-ISSN	15506606
DOI	10.4049/jimmunol.1102630
Journal	The Journal of Immunology
Issue Number	2
Volume Number	188
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2012-01-15
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Antigens, Cd274 Deficiency Genetics Cd8-positive T-lymphocytes Immunology Transplantation Cell Movement Cell Proliferation Graft Vs Host Disease Hepatocytes Animals Physiology Pathology Graft Survival Metabolism Liver Transplantation Lymphocyte Activation Mice Mice, Inbred Balb C Mice, Inbred C57bl Mice, Knockout Mice, Transgenic Transplantation Tolerance Up-regulation Research Support, Non-u.s. Gov't Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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Loss of B7-H1 expression by recipient parenchymal cells leads to expansion of infiltrating donor CD8+ T cells and persistence of GVHD

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Loss of B7-H1 expression by recipient parenchymal cells leads to expansion of infiltrating donor CD8+ T cells and persistence of graft-versus-host disease.