NDLI: Isolation of human CD4/CD8 double-positive, graft-versus-host disease-protective, minor histocompatibility antigen-specific regulatory T cells and of a novel HLA-DR7-restricted HY-specific CD4 clone.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Yuruker, Ozel Tiberghien, Pierre Scott, Diane Simpson, Elizabeth Eljaafari, Assia Farre, Annie Rigal, Dominique Thomas, Xavier Addey, Caroline Ferrand, Christophe Tartelin, Marie-Laure
Description	Country affiliation: France Author Affiliation: Eljaafari A ( Etablissement Français du Sang Rhone Alpes, HLA Department, Lyon 69007, France. assia.eljaafari@univ-lyon1.fr)
Abstract	Minor histocompatibility (H) Ags are classically described as self-peptides derived from intracellular proteins that are expressed at the cell surface by MHC class I and class II molecules and that induce T cell alloresponses. We have isolated three different T cell populations from a skin biopsy of a patient suffering from acute graft-versus-host disease following sex-mismatched HLA-identical bone marrow transplantation. The first population was: 1) CD4(+)/CD8(+) double-positive; 2) specific for an HLA class I-restricted autosomal Ag; 3) expressed a Tr1 profile with high levels of IL-10, but low IL-2 and IFN-Î³; and 4) exerted regulatory function in the presence of recipient APCs. The second was CD8 positive, specific for an HLA class I-restricted autosomally encoded minor H Ag, but was only weakly cytotoxic. The third was CD4 single positive, specific for an HLA-DR7-restricted HY epitope and exerted both proliferative and cytotoxic functions. Identification of the peptide recognized by these latter cells revealed a new human HY epitope, TGKIINFIKFDTGNL, encoded by RPS4Y and restricted by HLA-DR7. In this paper, we show human CD4/CD8 double-positive, acute graft-versus-host disease-protective, minor H Ag-specific regulatory T cells and identify a novel HLA-DR7/ HY T cell epitope, encoded by RPS4Y, a potential new therapeutic target.
ISSN	00221767
e-ISSN	15506606
Journal	The Journal of Immunology
Issue Number	1
Volume Number	190
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2013-01-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Cd4-positive T-lymphocytes Immunology Cd8-positive T-lymphocytes Epitopes, T-lymphocyte Graft Vs Host Disease Prevention & Control H-y Antigen Hla-dr7 Antigen Genetics Minor Histocompatibility Antigens T-lymphocytes, Regulatory Antigen Presentation Cytology Metabolism Cell Line, Transformed Cell Separation Clone Cells Pathology Hla-drb1 Chains Research Support, Non-u.s. Gov't Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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