NDLI: Memory CD4+ T cells are required for optimal NK cell effector functions against the opportunistic fungal pathogen Pneumocystis murina.

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Memory CD4+ T cells are required for optimal NK cell effector functions against the opportunistic fungal pathogen Pneumocystis murina.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Kelly, Michelle N. Zheng, Mingquan Shellito, Judd E. Ruan, Sanbao Kolls, Jay D'Souza, Alain
Description	Country affiliation: United States Author Affiliation: Kelly MN ( Section of Pulmonary and Critical Care Medicine, Department of Medicine, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA. mkelly3@lsuhsc.edu)
Abstract	Little is known about the role of NK cells or their interplay with other immune cells during opportunistic infections. Using our murine model of Pneumocystis pneumonia, we found that loss of NK cells during immunosuppression results in substantial Pneumocystis lung burden. During early infection of C57B/6 CD4(+) T cell-depleted mice, there were significantly fewer NK cells in the lung tissue compared with CD4(+) T cell-intact animals, and the NK cells present demonstrated decreased upregulation of the activation marker NKp46 and production of the effector cytokine, IFN-Î³. Furthermore, coincubation studies revealed a significant increase in fungal killing when NK cells were combined with CD4(+) T cells compared with either cell alone, which was coincident with a significant increase in perforin production by NK cells. Finally, however, we found through adoptive transfer that memory CD4(+) T cells are required for significant NK cell upregulation of the activation marker NK group 2D and production of IFN-Î³, granzyme B, and perforin during Pneumocystis infection. To the best of our knowledge, this study is the first to demonstrate a role for NK cells in immunity to Pneumocystis pneumonia, as well as to establish a functional relationship between CD4(+) T cells and NK cells in the host response to an opportunistic fungal pathogen.
ISSN	00221767
e-ISSN	15506606
DOI	10.4049/jimmunol.1200861
Journal	The Journal of Immunology
Issue Number	1
Volume Number	190
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2013-01-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Cd4-positive T-lymphocytes Immunology Microbiology Immunologic Memory Killer Cells, Natural Opportunistic Infections Pneumocystis Pneumonia, Pneumocystis Animals Transplantation Cell Communication Chronic Disease Pathology Lung Mice Mice, Inbred C57bl Mice, Knockout Mice, Scid Pathogenicity Research Support, N.i.h., Extramural Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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MEMORY CD4+T CELLS ARE REQUIRED FOR OPTIMAL NK CELL EFFECTOR FUNCTIONS AGAINST THE OPPORTUNISTIC FUNGAL PATHOGEN, PNEUMOCYSTIS MURINA

B Lymphocytes Are Required during the Early Priming of CD4+ T Cells for Clearance of Pneumocystis Infection in Mice.

A diametric role for OX40 in the response of effector/memory CD4+ T cells and regulatory T cells to alloantigen.

Eosinophils Contribute to Early Clearance of Pneumocystis murina Infection.

Helping themselves: optimal virus-specific CD4 T cell responses require help via CD4 T cell licensing of dendritic cells.

CD25+CD4+ T cells contribute to the control of memory CD8+ T cells.

Smad4 represses the generation of memory-precursor effector T cells but is required for the differentiation of central memory T cells.

CCR7 plays no appreciable role in trafficking of central memory CD4 T cells to lymph nodes.

Natural killer (NK)-dendritic cell interactions generate MHC class II-dressed NK cells that regulate CD4+ T cells.

Memory CD4+ T cells are required for optimal NK cell effector functions against the opportunistic fungal pathogen Pneumocystis murina.

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MEMORY CD4+T CELLS ARE REQUIRED FOR OPTIMAL NK CELL EFFECTOR FUNCTIONS AGAINST THE OPPORTUNISTIC FUNGAL PATHOGEN, PNEUMOCYSTIS MURINA

B Lymphocytes Are Required during the Early Priming of CD4+ T Cells for Clearance of Pneumocystis Infection in Mice.

A diametric role for OX40 in the response of effector/memory CD4+ T cells and regulatory T cells to alloantigen.

Eosinophils Contribute to Early Clearance of Pneumocystis murina Infection.

Helping themselves: optimal virus-specific CD4 T cell responses require help via CD4 T cell licensing of dendritic cells.

CD25+CD4+ T cells contribute to the control of memory CD8+ T cells.

Smad4 represses the generation of memory-precursor effector T cells but is required for the differentiation of central memory T cells.

CCR7 plays no appreciable role in trafficking of central memory CD4 T cells to lymph nodes.

Natural killer (NK)-dendritic cell interactions generate MHC class II-dressed NK cells that regulate CD4+ T cells.

Memory CD4+ T cells are required for optimal NK cell effector functions against the opportunistic fungal pathogen Pneumocystis murina.