NDLI: Nuclear translocation of MEK1 triggers a complex T cell response through the corepressor silencing mediator of retinoid and thyroid hormone receptor.

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Nuclear translocation of MEK1 triggers a complex T cell response through the corepressor silencing mediator of retinoid and thyroid hormone receptor.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Gorska, Magdalena M. Guo, Lei Liang, Qiaoling Alam, Rafeul Chen, Chaoyu Karim, Mohammad Zunayet
Description	Country affiliation: United States Author Affiliation: Guo L ( Division of Allergy and Immunology, Department of Medicine, National Jewish Health, Denver, CO 80206, USA.)
Abstract	MEK1 phosphorylates ERK1/2 and regulates T cell generation, differentiation, and function. MEK1 has recently been shown to translocate to the nucleus. Its nuclear function is largely unknown. By studying human CD4 T cells, we demonstrate that a low level of MEK1 is present in the nucleus of CD4 T cells under basal conditions. T cell activation further increases the nuclear translocation of MEK1. MEK1 interacts with the nuclear receptor corepressor silencing mediator of retinoid and thyroid hormone receptor (SMRT). MEK1 reduces the nuclear level of SMRT in an activation-dependent manner. MEK1 is recruited to the promoter of c-Fos upon TCR stimulation. Conversely, SMRT is bound to the c-Fos promoter under basal conditions and is removed upon TCR stimulation. We examined the role of SMRT in regulation of T cell function. Small interfering RNA-mediated knockdown of SMRT results in a biphasic effect on cytokine production. The production of the cytokines IL-2, IL-4, IL-10, and IFN-Î³ increases in the early phase (8 h) and then decreases in the late phase (48 h). The late-phase decrease is associated with inhibition of T cell proliferation. The late-phase inhibition of T cell activation is, in part, mediated by IL-10 that is produced in the early phase and, in part, by ß-catenin signaling. Thus, we have identified a novel nuclear function of MEK1. MEK1 triggers a complex pattern of early T cell activation, followed by a late inhibition through its interaction with SMRT. This biphasic dual effect most likely reflects a homeostatic regulation of T cell function by MEK1.
ISSN	00221767
e-ISSN	15506606
DOI	10.4049/jimmunol.1201657
Journal	The Journal of Immunology
Issue Number	1
Volume Number	190
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2013-01-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Active Transport, Cell Nucleus Immunology Cd4-positive T-lymphocytes Map Kinase Kinase 1 Physiology Nuclear Receptor Co-repressor 1 Nuclear Receptor Co-repressor 2 Antagonists & Inhibitors Genetics Enzymology Metabolism Down-regulation Gene Silencing Growth Inhibitors Lymphocyte Activation Promoter Regions, Genetic Protein Binding Proto-oncogene Proteins C-fos Research Support, N.i.h., Extramural Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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Nuclear Translocation of MEK1 Triggers a Complex T cell Response through the Co-repressor Silencing Mediator of Retinoid and Thyroid Hormone Receptor (SMRT)

Silencing mediator for retinoid and thyroid hormone receptor and nuclear receptor corepressor attenuate transcriptional activation by the beta-catenin-TCF4 complex.

Silencing Mediator for Retinoid and Thyroid Hormone Receptors Interacts with Octamer Transcription Factor-1 and Acts as a Transcriptional Repressor

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Nuclear Xenobiotic Receptor Pregnane X Receptor Locks Corepressor Silencing Mediator for Retinoid and Thyroid Hormone Receptors (SMRT) onto the CYP24A1 Promoter to Attenuate Vitamin D3 ActivationS⃞

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Silencing Mediator for Retinoid and Thyroid Hormone Receptor and Nuclear Receptor Corepressor Attenuate Transcriptional Activation by the β-Catenin-TCF4 Complex*

The Role of Histone Deacetylase 3 Complex in Nuclear Hormone Receptor Action

SMRTe, a silencing mediator for retinoid and thyroid hormone receptors-extended isoform that is more related to the nuclear receptor corepressor

Nuclear translocation of MEK1 triggers a complex T cell response through the corepressor silencing mediator of retinoid and thyroid hormone receptor.

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