NDLI: Impact of IgA constant domain on HIV-1 neutralizing function of monoclonal antibody F425A1g8.

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Impact of IgA constant domain on HIV-1 neutralizing function of monoclonal antibody F425A1g8.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Gawron, Melissa A. Cavacini, Lisa A. Yu, Xiaocong Posner, Marshall R. Wang, Rijian Duval, Mark Lewis, Christopher
Description	Country affiliation: United States Author Affiliation: Yu X ( Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA. xyu@bidmc.harvard.edu)
Abstract	With the majority of HIV infections resulting from mucosal transmission, induction of an effective mucosal immune response is thought to be pivotal in preventing transmission. HIV-specific IgA, but not IgG, has been detected in the genital tract, seminal fluid, urethral swabs, urine, and vaginal wash samples of HIV-negative sex workers and HIV-status discordant couples. Purified mucosal and plasma IgA from some individuals with highly exposed, persistently seronegative status can neutralize infection and present cross-clade neutralization activity, though present at low levels. We generated a CD4-induced human mAb, F425A1g8, and characterized the impact of its isotype variants on HIV neutralizing activity. The result showed that, in contrast to little neutralization by the F425A1g8 IgG1 in the absence of sCD4, the IgA1 variant of the Ab displayed significant independent neutralization activity against a range of HIV clade B isolates in the absence of sCD4. Studies of the neutralizing function of IgA isotypes, and the functional relationship between different antigenic epitopes and IgA Abs, may also suggest strategies for the intervention of virus transmission and spread within the mucosa of the host, as well as serve to inform the design of vaccine strategies that may be more effective at preventing mucosal transmission. This research clearly suggests that IgA isotype, because of its unique molecular structure, may play an important role in HIV neutralization.
ISSN	00221767
e-ISSN	15506606
DOI	10.4049/jimmunol.1201469
Journal	The Journal of Immunology
Issue Number	1
Volume Number	190
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2013-01-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Antibodies, Monoclonal Chemistry Physiology Hiv Antibodies Hiv-1 Immunology Immunoglobulin A Immunoglobulin Constant Regions Metabolism Binding Sites, Antibody Immunoglobulin Isotypes Neutralization Tests Research Support, N.i.h., Extramural Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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Impact of IgA Constant Domain on HIV-1 Neutralizing Function of Monoclonal Antibody F425A1g8 §

Impact of IgA constant domain on HIV-1 neutralizing function of monoclonal antibody F425-A1g8

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Impact of IgA constant domain on HIV-1 neutralizing function of monoclonal antibody F425A1g8.

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Impact of IgA Constant Domain on HIV-1 Neutralizing Function of Monoclonal Antibody F425A1g8 §

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