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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Ziegler, Steven F. Headley, Mark B. Han, Hongwei Zhou, Baohua Xu, Whitney Comeau, Michael R. |
| Description | Country affiliation: United States Author Affiliation: Han H ( Immunology Program, Benaroya Research Institute, Seattle, WA 98101, USA.) |
| Abstract | The epithelial-derived cytokine thymic stromal lymphopoietin (TSLP) has been associated with the promotion of type 2 inflammation and the induction of allergic disease. In humans TSLP is elevated in the lungs of asthma patients and in the lesional skin of individuals with atopic dermatitis, whereas mice lacking TSLP responses are refractory to models of Th2-driven allergic disease. Although several cell types, including dendritic cells, basophils, and CD4 T cells, have been shown to respond to TSLP, its role in macrophage differentiation has not been studied. Type 2 cytokines (i.e., IL-4 and IL-13) can drive the differentiation of macrophages into alternatively activated macrophages (aaMs, also referred to as M2 macrophages). This population of macrophages is associated with allergic inflammation. We therefore reasoned that TSLP/TSLPR signaling may be involved in the differentiation and activation of aaMs during allergic airway inflammation. In this study, we report that TSLP changes the quiescent phenotype of pulmonary macrophages toward an aaM phenotype during TSLP-induced airway inflammation. This differentiation of airway macrophages was IL-13-, but not IL-4-, dependent. Taken together, we demonstrate in this study that TSLP/TSLPR plays a significant role in the amplification of aaMΦ polarization and chemokine production, thereby contributing to allergic inflammation. |
| ISSN | 00221767 |
| e-ISSN | 15506606 |
| DOI | 10.4049/jimmunol.1201808 |
| Journal | The Journal of Immunology |
| Issue Number | 3 |
| Volume Number | 190 |
| Language | English |
| Publisher | The American Association of Immunologists |
| Publisher Date | 2013-02-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Asthma Immunology Cytokines Pharmacology Macrophage Activation Macrophages Drug Effects Animals Chemically Induced Pathology Bronchoalveolar Lavage Fluid Cytology Cell Differentiation Cells, Cultured Chemokines Physiology Disease Models, Animal Drug Synergism Immunoglobulins Deficiency Genetics Interleukin-13 Interleukin-4 Lung Mice Mice, Inbred Balb C Mice, Knockout Ovalbumin Toxicity Receptors, Cytokine Stat6 Transcription Factor Signal Transduction Specific Pathogen-free Organisms Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't Discipline Immunology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Immunology |
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