NDLI: Two separate defects affecting true naive or virtual memory T cell precursors combine to reduce naive T cell responses with aging.

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Two separate defects affecting true naive or virtual memory T cell precursors combine to reduce naive T cell responses with aging.

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Two separate defects affecting true naive or virtual memory T cell precursors combine to reduce naive T cell responses with aging.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Wu, Angela Nikolich-Zugich, Janko Smithey, Megan J. Renkema, Kristin R. Li, Gang
Description	Author Affiliation: Renkema KR ( Department of Immunobiology, University of Arizona College of Medicine, Tucson, AZ 85724.)
Abstract	Naive T cell responses are eroded with aging. We and others have recently shown that unimmunized old mice lose ≥ 70% of Ag-specific CD8 T cell precursors and that many of the remaining precursors acquire a virtual (central) memory (VM; CD44(hi)CD62L(hi)) phenotype. In this study, we demonstrate that unimmunized TCR transgenic (TCRTg) mice also undergo massive VM conversion with age, exhibiting rapid effector function upon both TCR and cytokine triggering. Age-related VM conversion in TCRTg mice directly depended on replacement of the original TCRTg specificity by endogenous TCR rearrangements, indicating that TCR signals must be critical in VM conversion. Importantly, we found that VM conversion had adverse functional effects in both old wild-type and old TCRTg mice; that is, old VM, but not old true naive, T cells exhibited blunted TCR-mediated, but not IL-15-mediated, proliferation. This selective proliferative senescence correlated with increased apoptosis in old VM cells in response to peptide, but decreased apoptosis in response to homeostatic cytokines IL-7 and IL-15. Our results identify TCR as the key factor in differential maintenance and function of Ag-specific precursors in unimmunized mice with aging, and they demonstrate that two separate age-related defects--drastic reduction in true naive T cell precursors and impaired proliferative capacity of their VM cousins--combine to reduce naive T cell responses with aging.
ISSN	00221767
e-ISSN	15506606
DOI	10.4049/jimmunol.1301453
Journal	The Journal of Immunology
Issue Number	1
Volume Number	192
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2014-01-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Aging Immunology Immunologic Memory Precursor Cells, T-lymphoid T-lymphocytes Genetics Animals Cd8-positive T-lymphocytes Metabolism Cell Survival Drug Effects Cytokines Pharmacology Interleukin-2 Receptor Beta Subunit Mice Mice, Transgenic Receptors, Antigen, T-cell Receptors, Cytokine Signal Transduction Research Support, N.i.h., Extramural Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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