NDLI: Natural IgM prevents autoimmunity by enforcing B cell central tolerance induction.

Please wait, while we are loading the content...

TAM receptor-dependent regulation of SOCS3 and MAPKs contributes to pro-inflammatory cytokine downregulation following chronic NOD2 stimulation of human $macrophages^{}$

The inducible costimulator augments Tc17 cell responses to self and tumor tissue.

Alternatively spliced myeloid differentiation protein-2 inhibits TLR4-mediated lung inflammation.

Defining CD4 T cell memory by the epigenetic landscape of CpG DNA methylation.

The D0 immunoglobulin-like domain plays a central role for the stronger binding of KIR3DL2 to B27 free heavy chain dimers

Acquisition of activation receptor ligand by trogocytosis renders NK cells hyporesponsive.

Tim-1 is essential for induction and maintenance of IL-10 in regulatory B cells and their regulation of tissue inflammation.

Antibody-opsonized bacteria evoke an inflammatory dendritic cell phenotype and polyfunctional Th cells by cross-talk between TLRs and FcRs.

ß-arrestin1 is critical for the full activation of NLRP3 and NLRC4 inflammasomes.

Heme exporter FLVCR is required for T cell development and peripheral survival.

Defective selection of thymic regulatory T cells accompanies autoimmunity and pulmonary infiltrates in Tcra-deficient mice double transgenic for human La/Sjögren's syndrome-B and human La-specific TCR.

Duox1-derived H2O2 modulates Cxcl8 expression and neutrophil recruitment via JNK/c-JUN/AP-1 signaling and chromatin modifications.

High-mobility group box 1: a novel target for treatment of Pseudomonas aeruginosa keratitis.

A novel regulatory macrophage induced by a helminth molecule instructs IL-10 in CD4+ T cells and protects against mucosal inflammation.

Cytotoxic mediators in paradoxical HIV-tuberculosis immune reconstitution inflammatory syndrome.

Vaccine adjuvant MF59 promotes retention of unprocessed antigen in lymph node macrophage compartments and follicular dendritic cells.

5-lipoxygenase is a direct target of miR-19a-3p and miR-125b-5p.

The unappreciated intracellular lifestyle of Blastomyces dermatitidis.

TLR signaling modulates side effects of anticancer therapy in the small intestine.

Selective blockade of CD28-mediated T cell costimulation protects rhesus monkeys against acute fatal experimental autoimmune encephalomyelitis.

Monitoring and cell-specific deletion of C5aR1 using a novel floxed GFP-C5aR1 reporter knock-in mouse.

Cutting edge: stage-specific requirement of IL-18 for antiviral NK cell expansion.

Macronutrient deprivation modulates antigen trafficking and immune recognition through HSC70 accessibility

Cutting Edge: identification of neutrophil PGLYRP1 as a ligand for TREM-1.

ß-Defensin 1 plays a role in acute mucosal defense against Candida albicans.

Cancer-associated oxidoreductase ERO1- drives the production of tumor-promoting myeloid-derived suppressor cells via oxidative protein folding.

Cutting Edge: the BTLA-HVEM regulatory pathway interferes with protective immunity to intestinal Helminth infection.

ShcA regulates late stages of T cell development and peripheral CD4+ T cell numbers.

CX3CR1 reduces kidney fibrosis by inhibiting local proliferation of profibrotic macrophages.

Activation-specific metabolic requirements for NK Cell IFN-Î³ production.

IRAK-M promotes alternative macrophage activation and fibroproliferation in bleomycin-induced lung injury.

IRF5 deficiency ameliorates lupus but promotes atherosclerosis and metabolic dysfunction in a mouse model of lupus-associated atherosclerosis.

Elevation of c-MYC disrupts HLA class II-mediated immune recognition of human B cell tumors.

Alterations in antigen-specific naive CD4 T cell precursors after sepsis impairs their responsiveness to pathogen challenge.

NFAT1 and JunB cooperatively regulate IL-31 gene expression in CD4+ T cells in health and disease.

PTEN is a negative regulator of NK cell cytolytic function.

Expansion of an atypical NK cell subset in mouse models of systemic lupus erythematosus.

Deficiency of antigen-specific B cells results in decreased Trypanosoma cruzi systemic but not mucosal immunity due to CD8 T cell exhaustion.

Neurturin influences inflammatory responses and airway remodeling in different mouse asthma models.

Loss of mouse P2Y4 nucleotide receptor protects against myocardial infarction through endothelin-1 downregulation.

Natural IgM prevents autoimmunity by enforcing B cell central tolerance induction.

Memory T cells specific for murine cytomegalovirus re-emerge after multiple challenges and recapitulate immunity in various adoptive transfer scenarios.

Evasion of innate cytosolic DNA sensing by a gammaherpesvirus facilitates establishment of latent infection.

Unique Ligand-Binding Property of the Human IgM Fc Receptor (FcμR)

Porcine ß-defensin 2 attenuates inflammation and mucosal lesions in dextran sodium sulfate-induced colitis.

Transplanted bone marrow-derived circulating PDGFR + cells restore type VII collagen in recessive dystrophic epidermolysis bullosa mouse skin graft.

Engulfment of activated apoptotic cells abolishes TGF-ß-mediated immunoregulation via the induction of IL-6.

Cutting Edge: DNase II deficiency prevents activation of autoreactive B cells by double-stranded DNA endogenous ligands.

A nonhuman primate scrub typhus model: protective immune responses induced by pKarp47 DNA vaccination in cynomolgus macaques.

JNK regulatory molecule G5PR induces IgG autoantibody-producing plasmablasts from peritoneal B1a cells.

miR-24, miR-30b, and miR-142-3p regulate phagocytosis in myeloid inflammatory cells.

In vivo 4-1BB deficiency in myeloid cells enhances peripheral T cell proliferation by increasing IL-15.

Barcoding of live human peripheral blood mononuclear cells for multiplexed mass cytometry.

PP6 controls T cell development and homeostasis by negatively regulating distal TCR signaling.

Recombinant thrombomodulin inhibits lipopolysaccharide-induced inflammatory response by blocking the functions of CD14.

Neutrophil IL-1β processing induced by pneumolysin is mediated by the NLRP3/ASC inflammasome and caspase-1 activation, and is dependent on $K^{+}$ efflux

Positive feedback regulation of type I IFN production by the IFN-inducible DNA sensor cGAS.

Fibroblastic reticular cells: organization and regulation of the T lymphocyte life cycle.

B10 cells: a functionally defined regulatory B cell subset.

Correction: A238L Inhibits NF-ATc2, NF-κB, and c-Jun Activation through a Novel Mechanism Involving Protein Kinase C-Î¸-Mediated Up-Regulation of the Amino-Terminal Transactivation Domain of p300.

Correction: Dual Function of CD70 in Viral Infection: Modulator of Early Cytokine Responses and Activator of Adaptive Responses.

Year: 2015 Volume: 194 Issue: 3

Year: 2015 Volume: 194 Issue: 2

Year: 2015 Volume: 194 Issue: 1

Year: 2014 Volume: 193

Year: 2014 Volume: 192

Year: 2013 Volume: 191

Year: 2013 Volume: 190

Year: 2012 Volume: 189

Year: 2012 Volume: 188

Year: 2011 Volume: 187

Year: 2011 Volume: 186

Year: 2010 Volume: 185

Year: 2010 Volume: 184

Year: 2009 Volume: 183

Year: 2009 Volume: 182

Year: 2008 Volume: 181

Natural IgM prevents autoimmunity by enforcing B cell central tolerance induction.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Baumgarth, Nicole Nguyen, Trang T. T. Elsner, Rebecca A.
Description	Author Affiliation: Nguyen TT ( Center for Comparative Medicine, University of California, Davis, Davis, CA 95616); Elsner RA ( Center for Comparative Medicine, University of California, Davis, Davis, CA 95616); Baumgarth N ( Center for Comparative Medicine, University of California, Davis, Davis, CA 95616)
Abstract	It is unclear why selective deficiency in secreted (s)IgM causes Ab-mediated autoimmunity. We demonstrate that sIgM is required for normal B cell development and selection. The CD5(+) B cells that were previously shown to accumulate in body cavities of sIgM(-/-) mice are not B-1a cells, but CD19(int), CD43(-), short-lived, BCR signaling-unresponsive anergic B-2 cells. Body cavity B-1 cells were >10-fold reduced, including VH11(+) and phosphotidylcholine-specific B-1a cells, whereas splenic B-1 cells were unaffected and marginal zone B cells increased. Follicular B cells had higher turnover rates, survived poorly after adoptive transfer, and were unresponsiveness to BCR stimulation in vitro. sIgM bound to B cell precursors and provided a positive signal to overcome a block at the pro/pre-B stage and during IgVH repertoire selection. Polyclonal IgM rescued B cell development and returned autoantibody levels to near normal. Thus, natural IgM deficiency causes primary autoimmune disease by altering B cell development, selection, and central tolerance induction.
ISSN	00221767
e-ISSN	15506606
DOI	10.4049/jimmunol.1401880
Journal	The Journal of Immunology
Issue Number	4
Volume Number	194
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2015-02-15
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Autoimmunity Immunology B-lymphocyte Subsets B-lymphocytes Central Tolerance Immunoglobulin M Animals Autoantibodies Autoimmune Diseases Cell Separation Clonal Anergy Enzyme-linked Immunosorbent Assay Flow Cytometry Immune Tolerance Mice Mice, Inbred C57bl Mice, Knockout Real-time Polymerase Chain Reaction Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Anti-CD79 antibody induces B cell anergy that protects against autoimmunity.

Modulation of peripheral B cell tolerance by CD72 in a murine model.

General Approach for Tetramer-Based Identification of Autoantigen-Reactive B Cells: Characterization of La- and snRNP-Reactive B Cells in Autoimmune BXD2 Mice.

Antigen-specific suppression of humoral immunity by anergic Ars/A1 B cells.

Quorum sensing contributes to activated IgM-secreting B cell homeostasis.

Ly-1 B cells: functionally distinct lymphocytes that secrete IgM autoantibodies.

Regulatory roles for NKT cell ligands in environmentally induced autoimmunity.

Regulation of B cell tolerance by 129-derived chromosome 1 loci in C57BL/6 mice.

Tolerant anti-insulin B cells are effective APCs.

Natural IgM prevents autoimmunity by enforcing B cell central tolerance induction.

Similar Documents

Anti-CD79 antibody induces B cell anergy that protects against autoimmunity.

Modulation of peripheral B cell tolerance by CD72 in a murine model.

General Approach for Tetramer-Based Identification of Autoantigen-Reactive B Cells: Characterization of La- and snRNP-Reactive B Cells in Autoimmune BXD2 Mice.

Antigen-specific suppression of humoral immunity by anergic Ars/A1 B cells.

Quorum sensing contributes to activated IgM-secreting B cell homeostasis.

Ly-1 B cells: functionally distinct lymphocytes that secrete IgM autoantibodies.

Regulatory roles for NKT cell ligands in environmentally induced autoimmunity.

Regulation of B cell tolerance by 129-derived chromosome 1 loci in C57BL/6 mice.

Tolerant anti-insulin B cells are effective APCs.

Natural IgM prevents autoimmunity by enforcing B cell central tolerance induction.