NDLI: Cutting Edge: identification of neutrophil PGLYRP1 as a ligand for TREM-1.

Please wait, while we are loading the content...

TAM receptor-dependent regulation of SOCS3 and MAPKs contributes to pro-inflammatory cytokine downregulation following chronic NOD2 stimulation of human $macrophages^{}$

The inducible costimulator augments Tc17 cell responses to self and tumor tissue.

Alternatively spliced myeloid differentiation protein-2 inhibits TLR4-mediated lung inflammation.

Defining CD4 T cell memory by the epigenetic landscape of CpG DNA methylation.

The D0 immunoglobulin-like domain plays a central role for the stronger binding of KIR3DL2 to B27 free heavy chain dimers

Acquisition of activation receptor ligand by trogocytosis renders NK cells hyporesponsive.

Tim-1 is essential for induction and maintenance of IL-10 in regulatory B cells and their regulation of tissue inflammation.

Antibody-opsonized bacteria evoke an inflammatory dendritic cell phenotype and polyfunctional Th cells by cross-talk between TLRs and FcRs.

ß-arrestin1 is critical for the full activation of NLRP3 and NLRC4 inflammasomes.

Heme exporter FLVCR is required for T cell development and peripheral survival.

Defective selection of thymic regulatory T cells accompanies autoimmunity and pulmonary infiltrates in Tcra-deficient mice double transgenic for human La/Sjögren's syndrome-B and human La-specific TCR.

Duox1-derived H2O2 modulates Cxcl8 expression and neutrophil recruitment via JNK/c-JUN/AP-1 signaling and chromatin modifications.

High-mobility group box 1: a novel target for treatment of Pseudomonas aeruginosa keratitis.

A novel regulatory macrophage induced by a helminth molecule instructs IL-10 in CD4+ T cells and protects against mucosal inflammation.

Cytotoxic mediators in paradoxical HIV-tuberculosis immune reconstitution inflammatory syndrome.

Vaccine adjuvant MF59 promotes retention of unprocessed antigen in lymph node macrophage compartments and follicular dendritic cells.

5-lipoxygenase is a direct target of miR-19a-3p and miR-125b-5p.

The unappreciated intracellular lifestyle of Blastomyces dermatitidis.

TLR signaling modulates side effects of anticancer therapy in the small intestine.

Selective blockade of CD28-mediated T cell costimulation protects rhesus monkeys against acute fatal experimental autoimmune encephalomyelitis.

Monitoring and cell-specific deletion of C5aR1 using a novel floxed GFP-C5aR1 reporter knock-in mouse.

Cutting edge: stage-specific requirement of IL-18 for antiviral NK cell expansion.

Macronutrient deprivation modulates antigen trafficking and immune recognition through HSC70 accessibility

Cutting Edge: identification of neutrophil PGLYRP1 as a ligand for TREM-1.

ß-Defensin 1 plays a role in acute mucosal defense against Candida albicans.

Cancer-associated oxidoreductase ERO1- drives the production of tumor-promoting myeloid-derived suppressor cells via oxidative protein folding.

Cutting Edge: the BTLA-HVEM regulatory pathway interferes with protective immunity to intestinal Helminth infection.

ShcA regulates late stages of T cell development and peripheral CD4+ T cell numbers.

CX3CR1 reduces kidney fibrosis by inhibiting local proliferation of profibrotic macrophages.

Activation-specific metabolic requirements for NK Cell IFN-Î³ production.

IRAK-M promotes alternative macrophage activation and fibroproliferation in bleomycin-induced lung injury.

IRF5 deficiency ameliorates lupus but promotes atherosclerosis and metabolic dysfunction in a mouse model of lupus-associated atherosclerosis.

Elevation of c-MYC disrupts HLA class II-mediated immune recognition of human B cell tumors.

Alterations in antigen-specific naive CD4 T cell precursors after sepsis impairs their responsiveness to pathogen challenge.

NFAT1 and JunB cooperatively regulate IL-31 gene expression in CD4+ T cells in health and disease.

PTEN is a negative regulator of NK cell cytolytic function.

Expansion of an atypical NK cell subset in mouse models of systemic lupus erythematosus.

Deficiency of antigen-specific B cells results in decreased Trypanosoma cruzi systemic but not mucosal immunity due to CD8 T cell exhaustion.

Neurturin influences inflammatory responses and airway remodeling in different mouse asthma models.

Loss of mouse P2Y4 nucleotide receptor protects against myocardial infarction through endothelin-1 downregulation.

Natural IgM prevents autoimmunity by enforcing B cell central tolerance induction.

Memory T cells specific for murine cytomegalovirus re-emerge after multiple challenges and recapitulate immunity in various adoptive transfer scenarios.

Evasion of innate cytosolic DNA sensing by a gammaherpesvirus facilitates establishment of latent infection.

Unique Ligand-Binding Property of the Human IgM Fc Receptor (FcμR)

Porcine ß-defensin 2 attenuates inflammation and mucosal lesions in dextran sodium sulfate-induced colitis.

Transplanted bone marrow-derived circulating PDGFR + cells restore type VII collagen in recessive dystrophic epidermolysis bullosa mouse skin graft.

Engulfment of activated apoptotic cells abolishes TGF-ß-mediated immunoregulation via the induction of IL-6.

Cutting Edge: DNase II deficiency prevents activation of autoreactive B cells by double-stranded DNA endogenous ligands.

A nonhuman primate scrub typhus model: protective immune responses induced by pKarp47 DNA vaccination in cynomolgus macaques.

JNK regulatory molecule G5PR induces IgG autoantibody-producing plasmablasts from peritoneal B1a cells.

miR-24, miR-30b, and miR-142-3p regulate phagocytosis in myeloid inflammatory cells.

In vivo 4-1BB deficiency in myeloid cells enhances peripheral T cell proliferation by increasing IL-15.

Barcoding of live human peripheral blood mononuclear cells for multiplexed mass cytometry.

PP6 controls T cell development and homeostasis by negatively regulating distal TCR signaling.

Recombinant thrombomodulin inhibits lipopolysaccharide-induced inflammatory response by blocking the functions of CD14.

Neutrophil IL-1β processing induced by pneumolysin is mediated by the NLRP3/ASC inflammasome and caspase-1 activation, and is dependent on $K^{+}$ efflux

Positive feedback regulation of type I IFN production by the IFN-inducible DNA sensor cGAS.

Fibroblastic reticular cells: organization and regulation of the T lymphocyte life cycle.

B10 cells: a functionally defined regulatory B cell subset.

Correction: A238L Inhibits NF-ATc2, NF-κB, and c-Jun Activation through a Novel Mechanism Involving Protein Kinase C-Î¸-Mediated Up-Regulation of the Amino-Terminal Transactivation Domain of p300.

Correction: Dual Function of CD70 in Viral Infection: Modulator of Early Cytokine Responses and Activator of Adaptive Responses.

Year: 2015 Volume: 194 Issue: 3

Year: 2015 Volume: 194 Issue: 2

Year: 2015 Volume: 194 Issue: 1

Year: 2014 Volume: 193

Year: 2014 Volume: 192

Year: 2013 Volume: 191

Year: 2013 Volume: 190

Year: 2012 Volume: 189

Year: 2012 Volume: 188

Year: 2011 Volume: 187

Year: 2011 Volume: 186

Year: 2010 Volume: 185

Year: 2010 Volume: 184

Year: 2009 Volume: 183

Year: 2009 Volume: 182

Year: 2008 Volume: 181

Cutting Edge: identification of neutrophil PGLYRP1 as a ligand for TREM-1.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Brandt, Cameron S. Kastrup, Jesper Kuijper, Joseph L. Tang, Xiaoting Xu, Wenfeng Fleetwood, Andrew J. Dantzler, Jeffrey L. Wagtmann, Nicolai R. Hjorth, Siv A. Heipel, Mark D. Wang, Camilla Read, Christine B. Hansen, Anker J. Stennicke, Vibeke W. Grell, Susanne N.
Description	Author Affiliation: Read CB ( Novo Nordisk A/S, DK-2760 Måløv, Denmark); Kuijper JL ( Novo Nordisk Research Center, Seattle, WA 98109.); Hjorth SA ( Novo Nordisk A/S, DK-2760 Måløv, Denmark); Heipel MD ( Novo Nordisk Research Center, Seattle, WA 98109.); Tang X ( Novo Nordisk Research Center, Seattle, WA 98109.); Fleetwood AJ ( Novo Nordisk A/S, DK-2760 Måløv, Denmark); Dantzler JL ( Novo Nordisk Research Center, Seattle, WA 98109.); Grell SN ( Novo Nordisk A/S, DK-2760 Måløv, Denmark); Kastrup J ( Novo Nordisk A/S, DK-2760 Måløv, Denmark); Wang C ( Novo Nordisk Research Center, Seattle, WA 98109.); Brandt CS ( Novo Nordisk Research Center, Seattle, WA 98109.); Hansen AJ ( Novo Nordisk A/S, DK-2760 Måløv, Denmark); Wagtmann NR ( Novo Nordisk A/S, DK-2760 Måløv, Denmark); Xu W ( Novo Nordisk Research Center, Seattle, WA 98109.); Stennicke VW ( Novo Nordisk A/S, DK-2760 Måløv, Denmark)
Abstract	Triggering receptor expressed on myeloid cells (TREM)-1 is an orphan receptor implicated in innate immune activation. Inhibition of TREM-1 reduces sepsis in mouse models, suggesting a role for it in immune responses triggered by bacteria. However, the absence of an identified ligand has hampered a full understanding of TREM-1 function. We identified complexes between peptidoglycan recognition protein 1 (PGLYRP1) and bacterially derived peptidoglycan that constitute a potent ligand capable of binding TREM-1 and inducing known TREM-1 functions. Interestingly, multimerization of PGLYRP1 bypassed the need for peptidoglycan in TREM-1 activation, demonstrating that the PGLYRP1/TREM-1 axis can be activated in the absence of bacterial products. The role for PGLYRP1 as a TREM-1 activator provides a new mechanism by which bacteria can trigger myeloid cells, linking two known, but previously unrelated, pathways in innate immunity.
ISSN	00221767
e-ISSN	15506606
DOI	10.4049/jimmunol.1402303
Journal	The Journal of Immunology
Issue Number	4
Volume Number	194
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2015-02-15
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Cytokines Immunology Immunity, Innate Membrane Glycoproteins Neutrophils Receptors, Immunologic Immunoprecipitation Ligands Surface Plasmon Resonance Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Cutting Edge: Identification of Neutrophil PGLYRP1 as a Ligand for TREM-1

Cytokines TNFα, IFNγ and IL-2 Are Responsible for Signal Transmission from the Innate Immunity Protein Tag7 (PGLYRP1) to Cytotoxic Effector Lymphocytes

N-Terminal Peptide of PGLYRP1/Tag7 Is a Novel Ligand for TREM-1 Receptor

Triggering receptor expressed on myeloid cells-1 (TREM-1) expression on gastric epithelium: implication for a role of TREM-1 in Helicobacter pylori infection.

TREM-1 activation alters the dynamics of pulmonary IRAK-M expression in vivo and improves host defense during pneumococcal pneumonia.

Translational Mini-Review Series on Vaccines for HIV: Harnessing innate immunity for HIV vaccine development.

HLA-B27 Homodimers and Free H Chains Are Stronger Ligands for Leukocyte Ig-like Receptor B2 than Classical HLA Class 1

Expression and function of triggering receptor expressed on myeloid cells-1 (TREM-1) on canine neutrophils.

Identification of Extracellular Actin As a Ligand for Triggering Receptor Expressed on Myeloid Cells-1 Signaling

Cutting Edge: identification of neutrophil PGLYRP1 as a ligand for TREM-1.

Similar Documents

Cutting Edge: Identification of Neutrophil PGLYRP1 as a Ligand for TREM-1

Cytokines TNFα, IFNγ and IL-2 Are Responsible for Signal Transmission from the Innate Immunity Protein Tag7 (PGLYRP1) to Cytotoxic Effector Lymphocytes

N-Terminal Peptide of PGLYRP1/Tag7 Is a Novel Ligand for TREM-1 Receptor

Triggering receptor expressed on myeloid cells-1 (TREM-1) expression on gastric epithelium: implication for a role of TREM-1 in Helicobacter pylori infection.

TREM-1 activation alters the dynamics of pulmonary IRAK-M expression in vivo and improves host defense during pneumococcal pneumonia.

Translational Mini-Review Series on Vaccines for HIV: Harnessing innate immunity for HIV vaccine development.

HLA-B27 Homodimers and Free H Chains Are Stronger Ligands for Leukocyte Ig-like Receptor B2 than Classical HLA Class 1

Expression and function of triggering receptor expressed on myeloid cells-1 (TREM-1) on canine neutrophils.

Identification of Extracellular Actin As a Ligand for Triggering Receptor Expressed on Myeloid Cells-1 Signaling

Cutting Edge: identification of neutrophil PGLYRP1 as a ligand for TREM-1.