NDLI: Bortezomib reduces pre-existing antibodies to recombinant immunotoxins in mice.

Please wait, while we are loading the content...

Year: 2017 Volume: 198

Year: 2016 Volume: 197

Year: 2016 Volume: 196

Year: 2015 Volume: 195

Year: 2015 Volume: 194

Year: 2015 Volume: 194 Issue: 12

Year: 2015 Volume: 194 Issue: 11

Year: 2015 Volume: 194 Issue: 10

Year: 2015 Volume: 194 Issue: 9

Year: 2015 Volume: 194 Issue: 8

Year: 2015 Volume: 194 Issue: 7

Year: 2015 Volume: 194 Issue: 6

Year: 2015 Volume: 194 Issue: 5

Year: 2015 Volume: 194 Issue: 4

Alkylating agent melphalan augments the efficacy of adoptive immunotherapy using tumor-specific CD4+ T cells.

The human fetal placenta promotes tolerance against the semiallogeneic fetus by inducing regulatory T cells and homeostatic M2 macrophages.

Bortezomib reduces pre-existing antibodies to recombinant immunotoxins in mice.

E3 Ubiquitin Ligase Cbl-b Regulates Thymic-Derived CD4+CD25+ Regulatory T Cell Development by Targeting Foxp3 for Ubiquitination.

Protective efficacy of individual CD8+ T cell specificities in chronic viral infection.

A RIPK3-caspase 8 complex mediates atypical pro-IL-1ß processing.

TAM receptor-dependent regulation of SOCS3 and MAPKs contributes to pro-inflammatory cytokine downregulation following chronic NOD2 stimulation of human $macrophages^{}$

The inducible costimulator augments Tc17 cell responses to self and tumor tissue.

Alternatively spliced myeloid differentiation protein-2 inhibits TLR4-mediated lung inflammation.

Defining CD4 T cell memory by the epigenetic landscape of CpG DNA methylation.

The D0 immunoglobulin-like domain plays a central role for the stronger binding of KIR3DL2 to B27 free heavy chain dimers

Acquisition of activation receptor ligand by trogocytosis renders NK cells hyporesponsive.

Tim-1 is essential for induction and maintenance of IL-10 in regulatory B cells and their regulation of tissue inflammation.

Antibody-opsonized bacteria evoke an inflammatory dendritic cell phenotype and polyfunctional Th cells by cross-talk between TLRs and FcRs.

ß-arrestin1 is critical for the full activation of NLRP3 and NLRC4 inflammasomes.

Heme exporter FLVCR is required for T cell development and peripheral survival.

Defective selection of thymic regulatory T cells accompanies autoimmunity and pulmonary infiltrates in Tcra-deficient mice double transgenic for human La/Sjögren's syndrome-B and human La-specific TCR.

Duox1-derived H2O2 modulates Cxcl8 expression and neutrophil recruitment via JNK/c-JUN/AP-1 signaling and chromatin modifications.

High-mobility group box 1: a novel target for treatment of Pseudomonas aeruginosa keratitis.

A novel regulatory macrophage induced by a helminth molecule instructs IL-10 in CD4+ T cells and protects against mucosal inflammation.

Cytotoxic mediators in paradoxical HIV-tuberculosis immune reconstitution inflammatory syndrome.

Vaccine adjuvant MF59 promotes retention of unprocessed antigen in lymph node macrophage compartments and follicular dendritic cells.

5-lipoxygenase is a direct target of miR-19a-3p and miR-125b-5p.

The unappreciated intracellular lifestyle of Blastomyces dermatitidis.

TLR signaling modulates side effects of anticancer therapy in the small intestine.

Selective blockade of CD28-mediated T cell costimulation protects rhesus monkeys against acute fatal experimental autoimmune encephalomyelitis.

Monitoring and cell-specific deletion of C5aR1 using a novel floxed GFP-C5aR1 reporter knock-in mouse.

Cutting edge: stage-specific requirement of IL-18 for antiviral NK cell expansion.

Macronutrient deprivation modulates antigen trafficking and immune recognition through HSC70 accessibility

Cutting Edge: identification of neutrophil PGLYRP1 as a ligand for TREM-1.

ß-Defensin 1 plays a role in acute mucosal defense against Candida albicans.

Cancer-associated oxidoreductase ERO1- drives the production of tumor-promoting myeloid-derived suppressor cells via oxidative protein folding.

Cutting Edge: the BTLA-HVEM regulatory pathway interferes with protective immunity to intestinal Helminth infection.

ShcA regulates late stages of T cell development and peripheral CD4+ T cell numbers.

CX3CR1 reduces kidney fibrosis by inhibiting local proliferation of profibrotic macrophages.

Activation-specific metabolic requirements for NK Cell IFN-Î³ production.

IRAK-M promotes alternative macrophage activation and fibroproliferation in bleomycin-induced lung injury.

IRF5 deficiency ameliorates lupus but promotes atherosclerosis and metabolic dysfunction in a mouse model of lupus-associated atherosclerosis.

Elevation of c-MYC disrupts HLA class II-mediated immune recognition of human B cell tumors.

Alterations in antigen-specific naive CD4 T cell precursors after sepsis impairs their responsiveness to pathogen challenge.

NFAT1 and JunB cooperatively regulate IL-31 gene expression in CD4+ T cells in health and disease.

PTEN is a negative regulator of NK cell cytolytic function.

Expansion of an atypical NK cell subset in mouse models of systemic lupus erythematosus.

Deficiency of antigen-specific B cells results in decreased Trypanosoma cruzi systemic but not mucosal immunity due to CD8 T cell exhaustion.

Neurturin influences inflammatory responses and airway remodeling in different mouse asthma models.

Loss of mouse P2Y4 nucleotide receptor protects against myocardial infarction through endothelin-1 downregulation.

Natural IgM prevents autoimmunity by enforcing B cell central tolerance induction.

Memory T cells specific for murine cytomegalovirus re-emerge after multiple challenges and recapitulate immunity in various adoptive transfer scenarios.

Evasion of innate cytosolic DNA sensing by a gammaherpesvirus facilitates establishment of latent infection.

Unique Ligand-Binding Property of the Human IgM Fc Receptor (FcμR)

Porcine ß-defensin 2 attenuates inflammation and mucosal lesions in dextran sodium sulfate-induced colitis.

Transplanted bone marrow-derived circulating PDGFR + cells restore type VII collagen in recessive dystrophic epidermolysis bullosa mouse skin graft.

Engulfment of activated apoptotic cells abolishes TGF-ß-mediated immunoregulation via the induction of IL-6.

Cutting Edge: DNase II deficiency prevents activation of autoreactive B cells by double-stranded DNA endogenous ligands.

A nonhuman primate scrub typhus model: protective immune responses induced by pKarp47 DNA vaccination in cynomolgus macaques.

JNK regulatory molecule G5PR induces IgG autoantibody-producing plasmablasts from peritoneal B1a cells.

miR-24, miR-30b, and miR-142-3p regulate phagocytosis in myeloid inflammatory cells.

In vivo 4-1BB deficiency in myeloid cells enhances peripheral T cell proliferation by increasing IL-15.

Barcoding of live human peripheral blood mononuclear cells for multiplexed mass cytometry.

PP6 controls T cell development and homeostasis by negatively regulating distal TCR signaling.

Recombinant thrombomodulin inhibits lipopolysaccharide-induced inflammatory response by blocking the functions of CD14.

Neutrophil IL-1β processing induced by pneumolysin is mediated by the NLRP3/ASC inflammasome and caspase-1 activation, and is dependent on $K^{+}$ efflux

Positive feedback regulation of type I IFN production by the IFN-inducible DNA sensor cGAS.

Fibroblastic reticular cells: organization and regulation of the T lymphocyte life cycle.

B10 cells: a functionally defined regulatory B cell subset.

Correction: A238L Inhibits NF-ATc2, NF-κB, and c-Jun Activation through a Novel Mechanism Involving Protein Kinase C-Î¸-Mediated Up-Regulation of the Amino-Terminal Transactivation Domain of p300.

Correction: Dual Function of CD70 in Viral Infection: Modulator of Early Cytokine Responses and Activator of Adaptive Responses.

Year: 2015 Volume: 194 Issue: 3

Year: 2015 Volume: 194 Issue: 2

Year: 2015 Volume: 194 Issue: 1

Year: 2014 Volume: 193

Year: 2014 Volume: 192

Year: 2013 Volume: 191

Year: 2013 Volume: 190

Year: 2012 Volume: 189

Year: 2012 Volume: 188

Year: 2011 Volume: 187

Year: 2011 Volume: 186

Year: 2010 Volume: 185

Year: 2010 Volume: 184

Year: 2009 Volume: 183

Year: 2009 Volume: 182

Year: 2008 Volume: 181

Bortezomib reduces pre-existing antibodies to recombinant immunotoxins in mice.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Mason-Osann, Emily Pastan, Ira Manning, Michael L. Onda, Masanori
Description	Author Affiliation: Manning ML ( Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20894.); Mason-Osann E ( Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20894.); Onda M ( Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20894.); Pastan I ( Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20894 pastani@mail.nih.gov.)
Abstract	Recombinant immunotoxin (RIT) therapy is limited in patients by neutralizing Ab responses. Ninety percent of patients with normal immune systems make neutralizing Abs after one cycle of RIT, preventing repeated dosing. Furthermore, some patients have pre-existing Abs from environmental exposure to Pseudomonas exotoxin, the component of the RIT that elicits the neutralizing Ab response. Bortezomib is an U.S. Food and Drug Administration-approved proteasome inhibitor that selectively targets and kills plasma cells that are necessary for the neutralizing Ab response. We hypothesized that bortezomib may abrogate neutralizing Ab levels, making dosing of RIT possible in mice already immune to RIT. We immunized BALB/c mice with multiple doses of SS1P, a RIT whose Ab portion targets mesothelin. Mice with elevated Ab levels were separated into groups to receive saline, bortezomib, the pentostatin/cyclophosphamide (PC) regimen, or the bortezomib/PC (BPC) combination regimen. Four weeks after finishing therapy, plasma Ab levels were assayed, and bone marrow was harvested. The bortezomib and PC regimens significantly reduced Ab levels, and we observed fewer plasma cells in the bone marrow of bortezomib-treated mice but not in PC-treated mice. The BPC combination regimen almost completely eliminated Abs and further reduced plasma cells in the bone marrow. This regimen is more effective than individual regimens and may reduce Ab levels in patients with pre-existing neutralizing Abs to Pseudomonas exotoxin, allowing RIT treatment.
ISSN	00221767
e-ISSN	15506606
DOI	10.4049/jimmunol.1402324
Journal	The Journal of Immunology
Issue Number	4
Volume Number	194
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2015-02-15
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Antibodies, Monoclonal Immunology Antibodies, Neutralizing Blood Boronic Acids Pharmacology Proteasome Inhibitors Pyrazines Adp Ribose Transferases Animals Bacterial Toxins Bortezomib Enzyme-linked Immunosorbent Assay Exotoxins Immunotherapy Mice Mice, Inbred Balb C Recombinant Proteins Virulence Factors Research Support, N.i.h., Intramural Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in